Publications by authors named "Ji-Li Lu"
Background: Osteosarcoma (OS), the most common pediatric bone tumor, faces challenges with frequent relapse despite treatment advances. Identifying early diagnostic biomarkers and therapeutic targets is critical. The purpose of this study was to investigate the novel biomarkers for OS, and we also aimed to explore whether these biomarkers could potentially serve as the therapy targets.
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- Osteoarthritis (OA) is a prevalent condition in older adults, but the molecular mechanisms behind its development and progression are still unclear; this study explored these mechanisms using a competing endogenous RNA (ceRNA) network approach.
- Researchers analyzed various mRNA, miRNA, and lncRNA datasets to identify differentially expressed genes (DEGs) and constructed a ceRNA network to explore their biological functions through enrichment analyses, as well as assessing immune cell presence in OA versus healthy samples.
- Key findings revealed significant players like hsa-mir-425-3p and dual specificity phosphatase 1 in the ceRNA network, highlighting their roles in important biological processes linked to immune responses and OA progression, suggesting potential targets for further