Hematotoxicity and expression of genes involved in hematological malignancies in Mexican children environmentally exposed to benzene.

There is growing evidence that environmental benzene exposure is a risk factor for developing some hematological disorders, leukemia included. The aim of this study was to assess the variation in mRNA expression of a regulatory set of hematopoietic genes in children exposed to benzene and hematological parameters. In this study, 67 healthy children between the ages of 3 and 12 voluntarily participated.

Regulatory Effects of Endometriosis-Associated Genetic Variants: A Multi-Tissue eQTL Analysis.

Backgroud: Endometriosis is a chronic, estrogen-dependent inflammatory disease characterized by the ectopic presence of endometrial-like tissue. Although genome-wide association studies (GWAS) have identified susceptibility variants, their tissue-specific regulatory impact remains poorly understood.

Objective: To functionally characterize endometriosis-associated variants by exploring their regulatory effects as expression quantitative trait loci (eQTLs) across six physiologically relevant tissues: peripheral blood, sigmoid colon, ileum, ovary, uterus, and vagina.

Larvicidal and Adulticidal Activity of Essential Oils from Four Cuban Plants against Three Mosquito Vector Species.

Mosquitoes are one of the main vectors of many important diseases and their degree of resistance to chemical insecticides has increased. Nowadays, it has become crucial to identify novel plant larvicides with an eco-friendly impact. The components of essential oils from Jacq.

Chemical Composition and In Vitro and In Silico Antileishmanial Evaluation of the Essential Oil from Jacq. Stems.

Jacq. is an aromatic shrub that has been utilized in traditional medicine in the Bahamas, Jamaica, and Cuba. Recent studies have revealed the antiprotozoal potential of its leaves.

Inhibitory Effect on Nitric Oxide Release in LPS-Stimulated Macrophages and Free Radical Scavenging Activity of Jacq. Leaves.

Oxidative stress is an important component of many diseases including cancer, along with inflammatory and neurodegenerative processes. Natural antioxidants have emerged as promising substances to protect the human body against reactive oxygen and nitrogen species. The present study evaluates the inhibition of nitric oxide (NO) production in LPS-stimulated RAW 264.

Antiplasmodial activity of alkaloids from Croton linearis leaves.

Croton linearis is a shrub that grows in Caribbean regions, which is rich in metabolites such as alkaloids. The main aim of this study was to evaluate the antiplasmodial effect of alkaloids from this species. Three isoquinoline alkaloids, i.

Novel flavonol-3--methylethers from Griseb. (Rutaceae).

Griseb. is a tree endemic to Cuba, occasionally used in herbal medicine. Previously, the antitrypanosomal activity of a -hexane-2-butanone extract of leaves and of its constituent skimmianine were published.

Catastrophic antiphospholipid syndrome associated with systemic lupus erythematosus: a case-based review.

Antiphospholipid syndrome (APS) can occur as a primary disease or secondary to an underlying disease, such as systemic lupus erythematosus, or other systemic autoimmune diseases. Catastrophic APS refers to a rapid progression of the disease with the development of thrombotic events that affect three or more organs. This is the case of a 22-year-old woman without history of pregnancy.

Antioxidants in Plants: A Valorization Potential Emphasizing the Need for the Conservation of Plant Biodiversity in Cuba.

Plants are phytochemical hubs containing antioxidants, essential for normal plant functioning and adaptation to environmental cues and delivering beneficial properties for human health. Therefore, knowledge on the antioxidant potential of different plant species and their nutraceutical and pharmaceutical properties is of utmost importance. Exploring this scientific research field provides fundamental clues on (1) plant stress responses and their adaptive evolution to harsh environmental conditions and (2) (new) natural antioxidants with a functional versatility to prevent and treat human pathologies.

Development, larvicide activity, and toxicity in nontarget species of the Croton linearis Jacq essential oil nanoemulsion.

In this study, the essential oil (EO) from leaves of Croton linearis Jacq was extracted and characterized by GC/MS. The EO hydrophilic-lipophilic balance required (rHLB) for nanoemulsion (NE) development was determined by the Griffin' method. For evaluating the larvicidal effect against Aedes aegypti, the preparation process of NE was optimized, using a central composite design.

Disodium tetra-aqua-bis(sulfato)iron(II).

In the title compound, [FeNa(2)(SO(4))(2)(H(2)O)(4)], the Fe(2+) cation is situated on a centre of inversion and is hexa-coordinated by four O atoms from water mol-ecules and two O atoms from two sulfate anions in an octa-hedral geometry. The coordination environment of Na(+) comprises six O atoms in a more distorted octa-hedral arrangement, with Na-O distances between 2.368 (1) and 2.

Pseudo-merohedrally twinned tetrakis(1H-imidazole-kappaN3)bis(N-nitrocyanamidato-kappaN)copper(II).

Crystals of the title complex, [Cu(CN3O2)2(C3H4N2)4], the structure of which has been determined by single-crystal X-ray diffraction at 304 K, appear to be pseudo-merohedrally twinned. Transformation to a monoclinic C-centred cell was necessary in order to derive the twin law. Twin refinement in a triclinic unit cell significantly reduced the R value.