Prognostic Factors in Sinonasal Cancers: A Multicenter Pooled Analysis.

Objectives: Sinonasal cancers (SNC) are heterogeneous diseases with different clinical behavior. We aimed to identify prognostic factors in non-metastatic (M0)-SNC.

Methods: Electronic health records from M0-SNC patients treated with definitive surgery ± postoperative radiotherapy or chemoradiotherapy at two tertiary institutions were reviewed.

Effectiveness and Safety of First-Line Non-Bismuth Quadruple Concomitant Therapy Versus Single-Capsule Bismuth Quadruple Therapy.

Background: The V Spanish Consensus Conference on Helicobacter pylori recommended either a 14-day non-bismuth quadruple concomitant therapy (CT: proton pump inhibitor [PPI], clarithromycin, amoxicillin, and metronidazole) or a 10-day bismuth-containing quadruple therapy (Sc-BQT: PPI, bismuth, tetracycline, and metronidazole in a single capsule). The relative advantages of each remain uncertain.

Aim: To compare the effectiveness and safety of first-line empirical CT versus Sc-BQT in Spain.

Elucidating the association between TLR-4 expression and the clinical course of glioblastoma leptomeningeal disease.

Background: No treatment exists for leptomeningeal disease (LMD) occurring in a subset of glioblastoma (GBM) patients and portends to a very poor prognosis. This study investigated the association of the Toll-Like Receptor 4 (TLR-4) pro-inflammatory pathway in LMD secondary to GBM.

Methods: We interrogated relevant transcriptomic and proteomic datasets, and primary patient tissue and cerebrospinal fluid (CSF) specimens.

Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia.

Introduction: Sex differences are apparent in neurodegenerative diseases but have not been comprehensively characterized in frontotemporal dementia (FTD).

Methods: Participants included 337 adults with autosomal dominant FTD enrolled in the ALLFTD Consortium. Clinical assessments and plasma were collected annually for up to 6 years.

Synthesis, Characterization, and Biomolecular Interactions of a novel Copper(II) Complex: DNA and BSA Binding Studies.

This study synthesizes and characterizes the mononuclear complex [Cu(phen)₂(NO₃)]NO₃·H₂O using analytical techniques such as infrared spectroscopy (FT-IR), elemental analysis, molar conductivity measurements, and single-crystal X-ray crystallography. The complex exhibited 1:1 electrolyte behavior. X-ray crystallography revealed a distorted trigonal bipyramidal geometry around Cu(II), stabilized by two 1,10 phenanthroline ligands and a nitrate ion.

Luminescent Manganese(II) Iminophosphorane Derivatives.

The reaction between the iminophosphorane ligand -phenyl-1,1,1-triphenylphosphanimine (NPh=PPh) and anhydrous manganese(II) halides allowed the isolation of complexes with the general formula [MnX(NPh=PPh)] (X = Cl, Br, I). The compounds showed luminescence in the green region attributed to the T(G)→A(S) transition of the metal centre in the tetrahedral field, which was superimposed in the cases of X = Cl and X = Br on weak ligand-centred fluorescence. The emission and excitation spectra were compared with those of the free ligand and of the related zinc(II) bromo-complex.

Activating antiviral immune responses potentiates immune checkpoint inhibition in glioblastoma models.

Viral mimicry refers to the activation of innate antiviral immune responses due to the induction of endogenous retroelements (REs). Viral mimicry augments antitumor immune responses and sensitizes solid tumors to immunotherapy. Here, we found that targeting what we believe to be a novel, master epigenetic regulator, Zinc Finger Protein 638 (ZNF638), induces viral mimicry in glioblastoma (GBM) preclinical models and potentiates immune checkpoint inhibition (ICI).

Mercury Monohalides as Ligands in Transition Metal Complexes.

The main categories of transition metal-mercury heterometallic compounds are briefly summarized. The attention is focused on complexes and clusters where the {Hg-Y} fragment, where Y represents a halide atom, interacts with transition metals. Most of the structurally characterized derivatives are organometallic compounds where the transition metals belong to the Groups 6, 8, 9 and 10.

Targeting ZNF638 activates antiviral immune responses and potentiates immune checkpoint inhibition in glioblastoma.

Viral mimicry refers to the activation of innate anti-viral immune responses due to the induction of endogenous retroelement (RE) expression. Viral mimicry has been previously described to augment anti-tumor immune responses and sensitize solid tumors to immunotherapy including colorectal cancer, melanoma, and clear renal cell carcinoma. Here, we found that targeting a novel, master epigenetic regulator, Zinc Finger Protein 638 (ZNF638), induces viral mimicry in glioblastoma (GBM) preclinical models and potentiates immune checkpoint inhibition (ICI).

Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors.

STK17A is a novel uncharacterized member of the death-associated protein family of serine and threonine kinases. Overexpression of STK17A is observed in many cancers. We identified a lead compound that is based on a quinazoline core.

Antisense Oligonucleotides for Rapid Translation of Gene Therapy in Glioblastoma.

Purpose: The limited efficacy of current treatments for malignant brain tumors necessitates novel therapeutic strategies. This study aimed to assess the potential of antisense oligonucleotides (ASOs) as adjuvant therapy for high-grade gliomas, focusing on their CNS penetration and clinical translation prospects.

Methods: A comprehensive review of the existing literature was conducted to evaluate the implications of ASOs in neuro-oncology.

Use of Hydrogen Peroxide Vapour for Microbiological Disinfection in Hospital Environments: A Review.

Disinfection of nosocomial pathogens in hospitals is crucial to combat healthcare-acquired infections, which can be acquired by patients, visitors and healthcare workers. However, the presence of a wide range of pathogens and biofilms, combined with the indiscriminate use of antibiotics, presents infection control teams in healthcare facilities with ongoing challenges in the selection of biocides and application methods. This necessitates the development of biocides and innovative disinfection methods that overcome the shortcomings of conventional methods.

Luminescent Behavior of Zn(II) and Mn(II) Halide Derivatives of 4-Phenyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-Oxide and Single-Crystal X-ray Structure Determination of the Ligand.

The two enantiomers of chiral phosphonate 4-phenyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-oxide, O=PPh(BINOL), were synthesized from the proper 1,1'-bi-2-naphtol (BINOL) enantiomer and characterized. The structure of the ()-enantiomer was elucidated by means of single-crystal X-ray diffraction. The reaction with anhydrous ZnBr afforded complexes having the general formula [ZnBr{O=PPh(BINOL)}] that showed intense fluorescence centered in the near-UV region rationalized on the basis of TD-DFT calculations.

Antitumor activity of copper(II) complexes with Schiff bases derived from N'-tosylbenzene-1,2-diamine.

The electrochemical oxidation of anodic metal copper in a solution of the ligands N-[(5-tert-butyl-2-hydroxyphenyl)methylidine]-N'-tosylbenzene-1,2-diamine [HL] and N-[(3,5-di-tert-butyl-2-hydroxyphenyl)methylidine]-N'-tosylbenzene-1,2-diamine, [HL] afforded homoleptic [CuL] compounds or solvate [CuLS] complexes. The addition to the electrochemical cell of coligands (L') such as 2,2'-bipyridine (2-bpy), 4,4'-bipyridine(4-bpy) or 1,10-phenanthroline (phen) allowed the synthesis, in one step, of heteroleptic [CuLL'] compounds, namely [CuL(HO)] (1), [CuL(2,2'-bpy)]⋅CHCN (2), [CuL(phen)]·HO (3), [CuL(4,4'-bpy)] (4), [CuL(CHOH)] (5), [CuL(2,2'-bpy)] (6), [CuL(phen)] (7) and [CuL(4,4'-bpy)] (8). The crystal structures of both ligands, HL, HL, and those of the complexes (2), (4), (5), (6) and (7) have been determined by X-ray diffraction techniques.

Ustekinumab and vedolizumab for the prevention of postoperative recurrence of Crohn's disease: Results from the ENEIDA registry.

Background: Anti-TNF agents are the only effective biological agents for the prevention of postoperative recurrence (POR) in Crohn's disease (CD). However, they are contraindicated or have been shown to fail in some patients. Although ustekinumab and vedolizumab were licensed for CD some years ago, data in this setting are scarce.

Immune checkpoint inhibitors-associated thrombosis in patients with lung cancer and melanoma: a study of the Spanish society of medical oncology (SEOM) thrombosis and cancer group.

Purpose: Immune Checkpoint Inhibitors (ICI) can be associated with thrombotic events, both venous and arterial (VTE/AT). However, there is a paucity of information regarding patients in routine clinical practice.

Methods/patients: Retrospective, multicenter study promoted by the Thrombosis and Cancer Section of the Spanish Society of Medical Oncology (SEOM).

Synthesis and photoluminescence of manganese(II) naphtylphosphonic diamide complexes.

Manganese(ii) halide complexes with N,N,N',N'-tetramethyl-P-naphtalen-2-ylphosphonic diamide were synthesized from anhydrous MnX2 salts (X = Cl, Br, I) and characterized. Single-crystal X-ray diffraction revealed in all the cases slightly distorted tetrahedral geometry of the coordination sphere. The photoluminescence spectra showed the superimposition of a green emission, related to the 4T1(4G) → 6A1(6S) transition of Mn(ii), with a band in the red range.

Phenotypic variation of transcriptomic cell types in mouse motor cortex.

Cortical neurons exhibit extreme diversity in gene expression as well as in morphological and electrophysiological properties. Most existing neural taxonomies are based on either transcriptomic or morpho-electric criteria, as it has been technically challenging to study both aspects of neuronal diversity in the same set of cells. Here we used Patch-seq to combine patch-clamp recording, biocytin staining, and single-cell RNA sequencing of more than 1,300 neurons in adult mouse primary motor cortex, providing a morpho-electric annotation of almost all transcriptomically defined neural cell types.

Intraventricular synchronism assessment by gated-SPECT myocardial perfusion imaging in cardiac resynchronization therapy. Does cardiomyopathy type influence results?

Purpose: To analyze the evolution post-cardiac resynchronization therapy (CRT) in left ventricular non-compaction (LVNC) cardiomyopathy (CM) patients compared to other types of CM, according to clinical and functional variables, by using gated-SPECT myocardial perfusion imaging (MPI).

Methods: Ninety-three patients (60 ± 11 years, 28% women) referred for pre-CRT assessment were studied and divided into three groups: 1 (non-ischemic CM with LVNC, 11 patients), 2 (ischemic CM, 28 patients), and 3 (non-ischemic CM, 53 patients). All were studied by a Tc-MIBI gated-SPECT MPI at rest pre-CRT implantation and 6 ± 1 months after, including intraventricular dyssynchrony assessment by phase analysis.

Light harvesting indolyl-substituted phosphoramide ligand for the enhancement of Mn(ii) luminescence.

The reaction of N,N,N',N'-tetramethyl-P-indol-1-ylphosphonic diamide (L) with Mn(ii) halides under mild conditions allowed the isolation of tetrahedral neutral complexes having the general formula [MnX2L2] (X = Cl, Br, I). The structures of the new coordination compounds were ascertained by single-crystal X-ray diffraction. The three species exhibited noticeable luminescence in the green region upon excitation with UV light, with emissions related to the Mn(ii) 4T1(4G) → 6A1(6S) transition, without appreciable luminescence from the coordinated ligands.

QT interval greater than 460 ms in multiple electrocardiograms during follow-up in patients with Brugada syndrome: What does it contribute?

Introduction: Corrected QT interval (QTc) >460 ms in the right precordial leads has been described as a predictor of malignant ventricular arrhythmias (MVA) in patients with Brugada syndrome (BrS).

Objective: To assess the presence of QTc>460 ms in multiple electrocardiograms (ECGs) during follow-up as a predictor of recurrence of MVA in patients with BrS.

Methods: The study group included 43 patients with BrS and an implantable cardioverter-defibrillator.

Author Correction: Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Primary malignant melanoma of the biliary tract: A case report and literature review.

Background: Primary malignant melanoma of the biliary tract (MBT) is a rare condition whose diagnosis requires excluding a primary origin in another location. This paper reviews the most important characteristics of MBT cases published in the literature and reports a new case. The patient reported here is the first case of primary malignant melanoma of the biliary tract with pulmonary metastasis treated with immunotherapy.

Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas.

Layer 4 (L4) of mammalian neocortex plays a crucial role in cortical information processing, yet a complete census of its cell types and connectivity remains elusive. Using whole-cell recordings with morphological recovery, we identified one major excitatory and seven inhibitory types of neurons in L4 of adult mouse visual cortex (V1). Nearly all excitatory neurons were pyramidal and all somatostatin-positive (SOM) non-fast-spiking interneurons were Martinotti cells.