Publications by authors named "Jessica de Assis Duarte"
Lectins from marine sponges have emerged as promising candidates for antimicrobial strategies, particularly against biofilm-forming pathogens. In this study, we report the purification, biochemical characterization, and antibiofilm properties of a new lectin (AfiL) isolated from . AfiL exhibited typical features of sponge lectins, including a β-sheet-rich secondary structure and a predominant oligomeric state in solution.
View Article and Find Full Text PDFStructural insights and antimicrobial synergy of a proto-galectin from the marine sponge Aiolochroia crassa.
Comp Biochem Physiol B Biochem Mol Biol
January 2025
Article Synopsis
- A novel lectin called AcrL was isolated from the marine sponge Aiolochroia crassa, which specifically binds to glycans with sialic acid and shows a typical galectin structure with carbohydrate-binding sites.
- AcrL demonstrated strong antibacterial effects by inhibiting biofilm formation in bacteria such as Staphylococcus aureus and Escherichia coli, with varying concentrations required for effectiveness.
- The lectin also enhances the efficacy of antibiotics and damages bacterial membranes, suggesting its potential as a new antibacterial agent in the fight against infections.
Structural characterization of a galectin from the marine sponge Aplysina lactuca (ALL) with synergistic effects when associated with antibiotics against bacteria.
Biochimie
November 2023
Lectins presents the ability to interact with glycans and trigger varied responses, including the inhibition of the development of various pathogens. Structural studies of these proteins are essential to better understand their functions. In marine sponges, so far only a few lectins have their primary structures completely determined.
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