A Possible Involvement of Sialidase in the Cell Response of the Antarctic Fungus P29 to Oxidative Stress.

Sialidases/neuraminidases remove terminal sialic acid residues from glycoproteins, glycolipids, and oligosaccharides. Our previous research has revealed the distribution of sialidase in non-clinical fungal isolates from different ecological niches, including Antarctica. Fungi adapted to extremely low temperatures possess defense mechanisms necessary for their survival such as the response against oxidative stress.

Response to Salt Stress of the Halotolerant Filamentous Fungus P13.

In recent years, there has been increasing interest in the study of extremophilic microorganisms, which include halophiles and halotolerants. These microorganisms, able to survive and thrive optimally in a wide range of environmental extremes, are polyextremophiles. In this context, one of the main reasons for studying them is to understand their adaptative mechanisms to stress caused by extreme living conditions.

The Role of Oxidative Stress in the Antifungal Activity of Two Mollusk Fractions on Resistant Fungal Strains.

Fungal infections are a significant global public health challenge because of their widespread occurrence, morbidity, and profound social and economic consequences. Antifungal resistance is also an increasing concern, posing a substantial risk to public health. There is a growing interest in searching for new antifungal drugs isolated from natural sources.

Halophilic Fungi-Features and Potential Applications.

Extremophiles are of significant scientific interest due to their unique adaptation to harsh environmental conditions and their potential for diverse biotechnological applications. Among these extremophiles, filamentous fungi adapted to high-salt environments represent a new and valuable source of enzymes, biomolecules, and biomaterials. While most studies on halophiles have focused on bacteria, reports on filamentous fungi remain limited.

Glucose Catabolite Repression Participates in the Regulation of Sialidase Biosynthesis by Antarctic Strain P29.

Sialidases (neuraminidases) catalyze the removal of terminal sialic acid residues from glycoproteins. Novel enzymes from non-clinical isolates are of increasing interest regarding their application in the food and pharmaceutical industry. The present study aimed to evaluate the participation of carbon catabolite repression (CCR) in the regulation of cold-active sialidase biosynthesis by the psychrotolerant fungal strain P29, isolated from Antarctica.

Exploring the mechanism underlying the antifungal activity of chitosan-based ZnO, CuO, and SiO nanocomposites as nanopesticides against Fusarium solani and Alternaria solani.

Chitosan-based nanocomposites (CS NCs) are gaining considerable attention as multifaceted antifungal agents. This study investigated the antifungal activity of NCs against two phytopathogenic strains: Fusarium solani (F. solani) and Alternaria solani (A.

Structural and functional characterization of cold-active sialidase isolated from Antarctic fungus P29.

The fungal strain, P29, isolated from a soil sample taken from Terra Nova Bay, Antarctica, was found to be a good producer of sialidase (P29). The present study was focused on the purification and structural characterization of the enzyme. P29 enzyme was purified using a Q-Sepharose column and fast performance liquid chromatography separation on a Mono Q column.

Catalase from the Antarctic Fungus I-9-Biosynthesis and Gene Characterization.

Extremely cold habitats are a serious challenge for the existing there organisms. Inhabitants of these conditions are mostly microorganisms and lower mycetae. The mechanisms of microbial adaptation to extreme conditions are still unclear.

Cold-active catalase from the psychrotolerant fungus Penicillium griseofulvum.

Cold-active catalase (CAT) elicits great interest because of its vast prospective at the medical, commercial, and biotechnological levels. The study paper reports the production of cold-active CAT by the strain Penicillium griseofulvum P29 isolated from Antarctic soil. Improved enzyme production was achieved by optimization of medium and culture conditions.

Moderate protective effect of Kyotorphin against the late consequences of intracerebroventricular streptozotocin model of Alzheimer's disease.

The established decrease in the level of endogenous kyotorphin (KTP) into the cerebrospinal fluid of patients with an advanced stage of Alzheimer's disease (AD) and the found neuroprotective activity of KTP suggested its participation in the pathophysiology of the disease. We aimed to study the effects of subchronic intracerebroventricular (ICV) treatment (14 days) with KTP on the behavioral, biochemical and histological changes in rats with streptozotocin (STZ-ICV)-induced model of sporadic AD (sAD). Three months after the administration of STZ-ICV, rats developed increased locomotor activity, decreased level of anxiety, impaired spatial and working memory.