Metastasis-associated wound repair promotes reciprocal activation of the lung epithelium and breast cancer metastases during outgrowth.

Unlabelled: When tumor cells colonize distant organs during metastasis, they interact extensively with surrounding cells. These interactions often change the behavior of surrounding cell populations which collectively induce a pro-tumor microenvironment that permits tumor cell outgrowth into overt, clinically detectable metastatic disease. The lung is one of the most common sites of breast cancer (BC) metastasis.

Parental understanding and attitudes following pharmacogenomic testing for pediatric neuropsychiatric patients.

This study explores parental understanding and attitudes around pharmacogenomic results in their child(ren). In-depth interviews with parents whose child(ren) had received a pharmacogenomic testing panel for management of neuropsychiatric medications were completed. Interviews were analyzed for themes and accuracy of understanding of results.

Operating room air delivery design to protect patient and surgical site results in particles released at surgical table having greater concentration along walls of the room than at the instrument tray.

Background: During the coronavirus disease 2019 (COVID-19) pandemic, recommendations have included that personnel not involved in procedures releasing airborne contaminants reduce their exposure by moving >2 m away. We tested whether air particle concentrations in operating rooms (ORs) are greater in the periphery, downstream from the supply airflow.

Methods: We analyzed data from 15 mock surgical procedures performed in 3 ORs.

Medicine and Media: The Ranitidine Debate.

Ranitidine has been the topic of recent media reports. Current findings, confirmed by the US Food and Drug Administration, indicate that some ranitidine products contain a substance that may be carcinogenic. Providers and patients require additional information on the risks of continuing therapy vs.

Examining a New Scale for Evaluating Taste in Children (TASTY).

Objectives: Pediatric medication taste impacts adherence, and current recommendations advocate for direct input from pediatric patients on medication taste during drug development. However, the lack of a widely used, validated measurement tool limits taste assessments. This protocol examines the validity of, and preferences for, a newly created self-report taste rating scale designed with images centered on taste (TASTY), compared with 2 existing hedonic taste scales.

Analyzing ICU Patient Room Environmental Quality Through Unoccupied, Normal, and Emergency Procedure Modes: An EQI Evaluation.

Background: There is increasing need to perform invasive surgical procedures in intensive care units (ICUs). Traditional ICUs differ from operating rooms (ORs) in several ways including air changes per hour (ACH) and pressurization. Increased ACH and positive pressurization of ORs intend to provide more aseptic environments for surgery.

Description of an Innovative Pediatric Individualized Therapeutics Clinic: Working toward Precision Drug Therapy.

The GOLDILOKs (Genomic and Ontogeny-Linked Dose Individualization and cLinical Optimization for KidS) Clinic aims to provide families and physicians with data to make more informed decisions with regard to pharmacological therapy by using innovative therapy and genomic technologies. The objectives are two-fold: (1) To describe the utility of the GOLDILOKs Clinic to referring prescribers by evaluating the type of referrals made to the GOLDILOKs Clinic and (2) to assess the most often utilized technologies (e.g.

Comparison of operating room air distribution systems using the environmental quality indicator method of dynamic simulated surgical procedures.

Background: Ensuring aseptic airborne environments for sterile fields and back instrument tables in operating rooms (ORs) is crucial to reducing microbial and particle contamination during surgery. Configurations of in-ceiling air delivery mechanisms impact the effectiveness of the system at eliminating contamination in critical zones.

Methods: The environmental quality indicator method was used to assess airborne environments in ORs equipped with a single large diffuser (SLD), a multidiffuser array (MDA), or a 4-way throw diffuser during dynamic, simulated surgical procedures.

Identification of bacteria using matrix-assisted laser desorption ionization time-of-flight mass spectrometry.

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS or simply MALDI)1 has become ubiquitous in the identification and analysis of biomacromolecules. As a technique that allows for the molecular weight determination of otherwise nonvolatile molecules, MALDI has had a profound impact in the molecular biosciences, especially in the field of proteomics. MALDI analysis of whole organisms allows for the generation of a phenotypic profile or "molecular fingerprint;" once established, these fingerprints can be used for identification purposes.

Characterization of human genetics courses for nonbiology majors in U.S. colleges and universities.

We characterized college human genetics courses for nonscience majors (NSM) by 1) determining the number of U.S. institutions offering courses and the number of students taking them; and 2) surveying course instructors on course demographics, content, materials, and pedagogies.

The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion.

A balance between fission and fusion events determines the morphology of mitochondria. In yeast, mitochondrial fission is regulated by the outer membrane-associated dynamin-related GTPase, Dnm1p. Mitochondrial fusion requires two integral outer membrane components, Fzo1p and Ugo1p.