Publications by authors named "Jenna N Sinkevitch"
Global Landscape Review of Serotype-Specific Invasive Pneumococcal Disease Surveillance among Countries Using PCV10/13: The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) Project.
Maria Deloria Knoll
,
Julia C Bennett
,
Maria Garcia Quesada
,
Eunice W Kagucia
,
Meagan E Peterson
,
Jenna N Sinkevitch
Microorganisms
April 2021
Article Synopsis
- The PSERENADE project focuses on global surveillance of invasive pneumococcal disease (IPD) to assess the impact of pneumococcal conjugate vaccines (PCV10/13).
- Among 138 countries using PCV10/13 as of 2018, 109 had IPD surveillance systems, with data collected from 76, enabling a comprehensive analysis of 240,639 post-vaccine IPD cases.
- The dataset will aid in understanding the effectiveness of the vaccines across different demographics and vaccination schedules, influencing future immunization policies globally and nationally.
Article Synopsis
- Serotype 1 (ST1) was a major cause of invasive pneumococcal disease (IPD) before the introduction of pneumococcal conjugate vaccines (PCVs), which include ST1 antigen.
- The PSERENADE project analyzed global data on ST1 IPD to assess the impact of PCV10/13 on disease rates, using advanced statistical methods.
- Results showed that after six years of using PCV10/13, there was a 95% reduction in ST1 IPD incidence across all age groups, but there is a need for more data from countries heavily affected by ST1 to improve the findings' applicability.