Exploring the beneficial effects of curcumin-based hydrogel beads in rats with rheumatoid arthritis induced by Freund's complete adjuvant.

The aim of this study was to examine the potential antioxidant activity of curcumin in therapeutic and preventive condition and its potential role as adjuvant to conventional drug methotrexate in treatment of rheumatoid arthritis (RA). The study included 104 female Wistar albino rats, 6 weeks old, body weight of 200-250 g, which were divided into 8 groups (n=13 in each group): 1. CTRL: negative control, 2.

Novel Insights into the Antibacterial Potential of Euphrasia officinalis L.

Regarding the resistance of bacteria to conventional antibiotics, the search for novel natural antibacterial agents is of significant importance. Herein, the antibacterial activity of ethanol and acetone extracts of the medicinal plant Euphrasia officinalis was evaluated. For the first time, the optimization of ultrasound-assisted extraction conditions to achieve a higher concentration of polyphenols and increase the antibacterial activity of E.

Extracts of Achillea millefolium L. inhibited biofilms and biofilm-related virulence factors of pathogenic bacteria isolated from wounds.

Biofilm is a surface-attached community of bacterial cells implicated in the pathogenesis of chronic infections and is highly resistant to antibiotics. New alternatives for controlling bacterial infections have been proposed focusing on the therapeutic properties of medicinal plants. Achillea millefollium (Yarrow) is a widespread plant species that is widely used in traditional medicine, especially for wound healing.

Montenegrin Digital Academic Innovation Hub: Experience in Supporting Digital Health Innovations.

Montenegrin Digital Academic Innovation Hub established within Erasmus+ project DigNEST is essential institutional support for developing innovations in the field of health in academic-business cooperation and partnership. Experience of 18 months in running Hub service provides preliminary results in analysis received innovation ideas, provided support and potentials/capacities in medical informatics advancements at national, regional and global level.

A comprehensive study on Geranium robertianum L. antibacterial potential.

Aims: The research aimed to optimize the ultrasound-assisted extraction of secondary metabolites and the antibacterial activity of the plant species Geranium robertianum. The phytochemical profiles of the optimized extracts, as well as their antibacterial and synergistic activity with an antibiotic and their potential mechanisms of action and cytotoxicity, were examined.

Methods And Results: Response Surface Methodology was used to optimize extraction conditions.

Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method.

This paper deals with the development of hydrophilic interaction liquid chromatographic (HILIC) method for the analysis of bilastine and its degradation impurities following Analytical Quality by Design approach. It is the first time that the method for bilastine and its impurities is proposed. The main objective was to identify the conditions where an adequate separation in minimal analysis duration could be achieved within a robust region.