Modulation of Voltage-Gated Sodium Channels from Sensory Neurons by Isoeugenol.

Isoeugenol is a phenylpropanoid that is commonly found in essential oils and has been commonly used as a flavoring agent in the culinary field and an anesthetic in fish. Yet despite its similarity to well-known eugenol, there is a lack of data regarding how isoeugenol would directly modulate neuronal excitability to interfere with pain signaling. Here, we studied the effects of isoeugenol on voltage-activated Na currents (I) as a means of starting to close the gap regarding the inhibitory properties of isoeugenol on neuronal excitability.