Mind the gap: The impact of discrepancy between current cognitive function and premorbid intelligence on psychosocial functioning in older age bipolar disorder.

Introduction: A discrepancy between current cognitive performance and premorbid IQ may indicate cognitive decline and relate to poorer psychosocial functioning in bipolar disorder, even when cognition appears unimpaired by standard norms. This study examined how objective cognition and IQ-cognition discrepancy relate to psychosocial functioning in older age bipolar disorder (OABD).

Methods: OABD underwent neurocognitive assessment, intelligence quotient (IQ) estimation (using vocabulary subtest of WAIS-III), and psychosocial functioning assessment via the Functioning Assessment Short Test (FAST).

Disentangling Subjective Sleep and Objective Cognition: Insights From Two Independent Cross-Sectional Cohorts of Remitted Bipolar Disorder.

Objectives: Cognitive impairment during remission in bipolar disorder (BD) hampers functional recovery. While diverse factors can impact these impairments, sleep disturbance is considered a key component. This cross-sectional report aimed to analyze the association between subjective sleep characteristics and objective cognitive impairment in two independent samples of remitted outpatients with BD.

Relationship and sexual satisfaction among patients with bipolar disorder and partners.

Objectives: Good interpersonal relationships are associated with improved functioning, quality of life, and a better prognosis in patients with bipolar disorder (BD). Little information is available regarding relationship satisfaction and sexual satisfaction within couples where 1 partner has BD.

Aim: This cross-sectional study aimed to examine relationship and sexual satisfaction in patients with BD and partners to patients with BD.

Network-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability.

Individuals with mood disorders present with cognitive impairment and functional disability, and small-scale studies underline aberrant cognitive control and default mode network activity as potential neuronal correlates underlying these deficiencies. The objectives of this large-scale, cross-sectional functional magnetic resonance imaging (fMRI) study were (I) to investigate the replicability of cognitive control network (CCN) hypo-activity and default mode network (DMN) hyper-activity in patients with mood disorders, and (II) to explore brain activity related to cognition and daily functioning across patients and controls. We pooled data from three studies conducted at the same study site, which resulted in a sample of 213 fully or partially remitted patients with mood disorders (189 with bipolar disorder, 24 with major depressive disorder) and 60 healthy controls (HC).

RNA editing-based biomarker blood test for the diagnosis of bipolar disorder: protocol of the EDIT-B study.

Introduction: Misdiagnosis of bipolar disorder (BD) can lead to ineffective treatment, increased risk of manic episodes, and increased severity. Objective diagnostic tests or precise tools to diagnose BD and distinguish it from major depressive disorder (MDD) in depressed patients are lacking.

Aim: To assess the external diagnostic validity of a blood-based test using an RNA epigenetic signature for the differential diagnosis of BD versus MDD in patients with depression.

Cognitive hierarchy in mood disorders and relations to daily functioning.

Cognitive impairment affects approximately 50 % of patients with mood disorders during remission, which correlates with poorer daily-life functioning. The hierarchical organisation of cognitive processes may mean that some cognitive deficits, e.g.

Exploring the effects of erythropoietin treatment on cortical thickness and hippocampal volume in patients with mood disorders undergoing electroconvulsive therapy: A randomized, placebo-controlled trial.

Background: Electroconvulsive therapy (ECT) is a highly effective treatment for severe depression. However, its utilization is limited to the most severely ill patients due to stigma, healthcare provider unfamiliarity, and concerns regarding cognitive side effects. Erythropoietin (EPO) is a promising add-on treatment during ECT due to its potential to increase neuroplasticity and cognition.

Effects of low-dose aspirin in bipolar disorder: study protocol for a randomised controlled trial (the A-Bipolar RCT).

Introduction: Accumulating data support the association between increased inflammation and bipolar disorder (BD), and preliminary data suggest that augmentation with low-dose aspirin (LDA) may protect against the onset and deterioration of BD via anti-inflammatory pathways. The A-bipolar randomised controlled trial (RCT) aims to investigate whether adding LDA to standard treatment improves day-to-day mood instability (MI) in BD.

Methods And Analysis: A two-arm, triple-blind, parallel-group, superiority RCT including 250 patients with newly diagnosed BD treated at the Copenhagen Affective Disorder Clinic, Denmark.

Amygdala and hippocampal substructure volumes and their association with improvement in mood symptoms in patients with mood disorders undergoing electroconvulsive therapy.

Electroconvulsive therapy (ECT) demonstrates favorable outcomes in the management of severe depressive disorders. ECT has been consistently associated with volumetric increases in the amygdala and hippocampus. However, the underlying mechanisms of these structural changes and their association to clinical improvement remains unclear.