Publications by authors named "Jazmyn A S Muhammad"
Article Synopsis
- Alzheimer's disease and related dementias (ADRD) impact both oral and gut microbiomes, with previous research mainly focused on gut dysbiosis, leaving oral microbiomes relatively neglected.
- This study analyzed the microbiomes of 32 participants (17 with cognitive impairment (CI) and 15 without (NC)) predominantly from the Hispanic population in San Antonio, using gene sequencing on stool and saliva samples to identify differences and associations with clinical measurements like fasting glucose and blood cholesterol.
- Results showed no significant clinical differences between CI and NC groups but revealed that CI participants had higher levels of certain oral bacteria and lower levels of gut bacteria with anti-inflammatory properties, suggesting potential distinct microbiome patterns in ADRD without finding synergistic effects between oral
Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age.
Alzheimers Dement
September 2024
Introduction: We investigated the associations of leptin markers with cognitive function and magnetic resonance imaging (MRI) measures of brain atrophy and vascular injury in healthy middle-aged adults.
Methods: We included 2262 cognitively healthy participants from the Framingham Heart Study with neuropsychological evaluation; of these, 2028 also had available brain MRI. Concentrations of leptin, soluble leptin receptor (sOB-R), and their ratio (free leptin index [FLI]), indicating leptin bioavailability, were measured using enzyme-linked immunosorbent assays.
A bidirectional communication exists between the brain and the gut, in which the gut microbiota influences cognitive function and vice-versa. Gut dysbiosis has been linked to several diseases, including Alzheimer's disease and related dementias (ADRD). However, the relationship between gut dysbiosis and markers of cerebral small vessel disease (cSVD), a major contributor to ADRD, is unknown.
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