Publications by authors named "Jayasree Peroth Jayaprakash"
N6-methyladenosine (m6A), one of the most prominent and reversible internal modifications of eukaryotic RNAs, has emerged as a critical regulator of gene expression in various cancers including oral squamous cell carcinoma (OSCC), wherein it shapes the tumor-specific epitranscriptomic gene-regulatory networks. METTL3, the primary m6A RNA methyltransferase, is significantly upregulated in OSCC cells leading to increased global m6A levels. Interestingly, METTL3 positively regulates miRNA biogenesis by modulating the processing of primary miRNAs in a m6A-dependent manner.
View Article and Find Full Text PDFArticle Synopsis
- N6-methyladenosine (m6A) is a crucial regulator in RNA functions and is linked to cancer, particularly head and neck squamous cell carcinoma (HNSCC), which has a low survival rate.
- Research indicates that m6A RNA methylation is elevated in HNSCC and affects various cancer-related processes like growth, cell death, and metastasis.
- The study suggests that m6A modifications can serve as potential biomarkers for diagnosing and predicting outcomes in HNSCC and aims to provide a thorough review of m6A's role in cancer mechanisms.
Eukaryotes carry hundreds of ribosomal RNA (rRNA) genes as tandem arrays, which generate rRNA for protein synthesis. Humans carry ∼ 400 rRNA gene copies and their expression is epigenetically regulated. Dysregulation of rRNA synthesis and ribosome biogenesis are characteristic features of cancers.
View Article and Find Full Text PDF