Publications by authors named "Javier Villegas-Salmeron"
Background: The purinergic ATP-gated P2X7 receptor (P2X7R) is increasingly recognized to contribute to pathological neuroinflammation and brain hyperexcitability. P2X7R expression has been shown to be increased in the brain, including both microglia and neurons, in experimental models of epilepsy and patients. To date, the cell type-specific downstream effects of P2X7Rs during seizures remain, however, incompletely understood.
View Article and Find Full Text PDFMicroRNAs have emerged as important regulators of the gene expression landscape in temporal lobe epilepsy. The mechanisms that control microRNA levels and influence target choice remain, however, poorly understood. RNA editing is a post-transcriptional mechanism mediated by the adenosine acting on RNA (ADAR) family of proteins that introduces base modification that diversifies the gene expression landscape.
View Article and Find Full Text PDFArticle Synopsis
- - Severe spermatogenic failure (SPGF) is a major cause of male infertility, leading to conditions like severe oligozoospermia (SO) and non-obstructive azoospermia (NOA), with most cases being of unknown origin.
- - This study investigated whether certain genetic variations in a gene related to spermatogenesis contribute to the risk of idiopathic SPGF, examining 727 SPGF cases and 1,058 unaffected men from the Iberian Peninsula.
- - Findings indicated a significant association between the minor allele frequency of a specific SNP and SO, suggesting that these genetic variations may affect spermatogenesis by altering the binding of key transcription factors, reinforcing the complexity of idiopathic SPGF.