Impact Modification of Poly(3-hydroxybutyrate) and Poly(3-hydroxybutyrate--3-hydroxyhexanoate) with Terratek FX1515 and Terratek GDH-B1FA.

Poly-(3-hydroxybutyrate) (PHB) and poly-(3-hydroxybutyrate--3-hydroxyhexanoate) (PHB--HHx) are promising alternatives to polyolefins due to their similar processing temperatures and mechanical properties. However, these polymers exhibit brittle failure and poor impact performance, limiting their uses for certain applications. In this work, industrially compostable impact modifiers Terratek FX1515 (FX1515) and Terratek GDH-B1FA (GDH-B1FA) were blended with PHB and PHB--HHx at 10, 20, and 30% w/w loadings to assess the mechanical performance of these polymers.

Development of impact resistant immediate release amorphous solid dispersion via hot-melt extrusion and injection molding.

Immediate release (IR) amorphous solid dispersion (ASD) tablets are currently manufactured via a multi-step process which includes hot melt extrusion (HME), grinding of the extrudate, sieving to achieve narrow particle size, blending with other excipients, and finally, direct compression. Due to the multi-step nature of the process, the production time and costs are much higher for ASD tablets than conventional tablets. Thus, a new and more efficient method of IR-ASD tablet production using HME coupled with injection molding (IM) was explored as a viable alternative.

Salmonella environmental persistence informs management relevant to avian and public health.

Salmonellosis is a significant public health threat responsible for millions of human cases annually but is also of significance to domestic and wild animals around the globe. While human infections are often foodborne, an increasing number of cases arise from environmental sources and contact with animals, including wild birds. Understanding the persistence of Salmonella in shared environments is critical for mitigating zoonotic transmission risks and understanding transmission dynamics for pets and free-living wildlife.

Biocomposite thermoplastic polyurethanes containing evolved bacterial spores as living fillers to facilitate polymer disintegration.

The field of hybrid engineered living materials seeks to pair living organisms with synthetic materials to generate biocomposite materials with augmented function since living systems can provide highly-programmable and complex behavior. Engineered living materials have typically been fabricated using techniques in benign aqueous environments, limiting their application. In this work, biocomposite fabrication is demonstrated in which spores from polymer-degrading bacteria are incorporated into a thermoplastic polyurethane using high-temperature melt extrusion.

Investigation of the Efficacy of a Biosensor Using Chicken Broth Samples.

Foodborne pathogens are microbes present in food that cause serious illness when the contaminated food is consumed. Among these pathogens, is one of the most serious bacterial pathogens, and causes severe illness. The techniques currently used for detection are based on common molecular biology tools that are not easy to implement for field use in food production and distribution facilities.

A Biologically Degradable and BioseniaticTM Feedstock for the High-Quality 3D Printing of Anatomical Models.

A Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) -based filament was evaluated as an alternative feedstock for Fused Deposition Modeling (FDM) of instructional and clinical medical specimens. PHBHHx-based prints of domestic cat vertebrae, skull bone, and an aortic arch cast were found comparable to conventional materials. PHBHHx-based filament and extrudate samples were evaluated for biological degradability, to meet the BioseniaticTM standard, defined by the University of Georgia New Materials Institute.

Weathering Effects on Degradation of Low-Density Polyethylene-Nanosilica Composite with Added Pro-oxidant.

Nanomaterials are increasingly used in polymer composites to enhance their properties, such as mechanical performance and durability, increased electrical conductivity, and improved optical clarity. Here results are presented of a study simulating effects of weathering on degradation of a nanosilica-low-density polyethylene (LDPE) composite. Release of nanosilica from LDPE composites is a potential source of toxic SiO.

Experimentally Determined Hansen Solubility Parameters of Biobased and Biodegradable Polyesters.

Hansen solubility parameters (HSP) of 15 commercially relevant biobased and biodegradable polyesters were experimentally determined by applying a novel approach to the classic solubility study method. In this approach, the extent of swelling in polymer films was determined using a simple equation based on the mass difference between swollen and nonswollen film samples to obtain normalized solvent uptake (). Using and HSPiP software, highly accurate HSP values were obtained for all 15 polyesters.

Recruitment of participants for dementia research: interprofessional perspectives from primary care-based memory clinics.

To understand clinician attitudes and the barriers that impede research recruitment from specialized primary care-based memory clinics. Clinicians completed a survey on attitudes and barriers to research recruitment from memory clinics. Comfort and willingness to recruit for research were low to moderate and were lower for drug trials than for observational and non-drug trials.

Comparative Study of the Biological Degradation of Poly(3-Hydroxybutyrate--3-Hydroxyhexanoate) Microbeads in Municipal Wastewater in Environmental and Controlled Laboratory Conditions.

From April to June 2019, poly(3-hydroxybutyrate--3-hydroxyhexanoate) (P3(HA)) microbead samples were exposed to an operational wastewater reclamation facility (WWRF) in an aerobic aeration basin in Athens, Georgia. Samples were withdrawn from the facility over a 13-week timeframe, and the particles were examined by Raman microscopy and thermogravimetric analysis/mass spectroscopy (TGA/MS) coupled with differential scanning calorimetry (DSC). The activated sludge from this facility was also used as an inoculum to examine carbon mineralization under controlled respirometry experiments to corroborate biological degradation rates determined from both the environmental and laboratory approach.

Can Standard Health Technology Assessment Approaches Help Guide the Price of Orphan Drugs in Canada? A Review of Submissions to the Canadian Agency for Drugs and Technologies in Health Common Drug Review.

Orphan drugs have high acquisition costs and when standard health technology assessment (HTA) approaches are used to assess their cost-effectiveness, they often appear not cost-effective. The Canadian Patented Medicine Review Board (PMPRB), through new regulations, will apply HTA assessment results from the Canadian Agency for Drugs and Technologies in Health (CADTH) and Institut national d'excellence en santé et en services sociaux (INESSS) when setting the maximum price that can be charged for Category I patented medicines (treatments with an annual cost exceeding 150% of GDP per capita of Canada or with expected annual market size >$50M). Through these regulations, PMPRB has also established a willingness-to-pay threshold of CAD$200,000 or CAD$150,000 per quality adjusted life year (QALY) for medications with a prevalence of no more than 1 in 2000 across all approved indications.

Distinct Mycoplasma pneumoniae Interactions with Sulfated and Sialylated Receptors.

is a cell wall-less bacterial pathogen of the conducting airways, causing bronchitis and atypical or "walking" pneumonia in humans. recognizes sialylated and sulfated oligosaccharide receptors to colonize the respiratory tract, but the contribution of the latter is particularly unclear. We used chamber slides coated with sulfatide (3--sulfogalactosylceramide) to provide a baseline for binding and gliding motility.

Photocross-linking Kinetics Study of Benzophenone Containing Zwitterionic Copolymers.

The kinetics of benzophenone (BP) and its derivatives have been widely studied in different solvents by nanosecond laser flash photolysis as well as in the polymer matrix. With the development of functional polymer coating, BP, as well as other photocross-linkers, has been incorporated into the polymer backbone or side chain to form the covalent connection between polymer coatings and substrates, which can improve the mechanical and chemical stability of the coatings. In this work, a series of BP pendent zwitterionic copolymer kinetics were investigated using UV-vis for the first time.

Multipronged Approach to Combat Catheter-Associated Infections and Thrombosis by Combining Nitric Oxide and a Polyzwitterion: a 7 Day In Vivo Study in a Rabbit Model.

The development of nonfouling and antimicrobial materials has shown great promise for reducing thrombosis and infection associated with medical devices with aims of improving device safety and decreasing the frequency of antibiotic administration. Here, the design of an antimicrobial, anti-inflammatory, and antithrombotic vascular catheter is assessed in vivo over 7 d in a rabbit model. Antimicrobial and antithrombotic activity is achieved through the integration of a nitric oxide donor, while the nonfouling surface is achieved using a covalently bound phosphorylcholine-based polyzwitterionic copolymer topcoat.

Fully Synthetic Heparan Sulfate-Based Neural Tissue Construct That Maintains the Undifferentiated State of Neural Stem Cells.

Heparin and heparan sulfate (HS) are attractive components for constructing biomaterials due to their ability to recruit and regulate the activity of growth factors. The structural and functional heterogeneity of naturally derived heparin and HS is, however, an impediment for the preparation of biomaterials for regenerative medicine. To address this problem, we have prepared hydrogels modified by well-defined synthetic HS-derived disaccharides.

Frailty Screening and Case-Finding for Complex Chronic Conditions in Older Adults in Primary Care.

With the aging population, escalating demand for seniors' care and limited specialist resources, new care delivery models are needed to improve capacity for primary health care for older adults. This paper describes the "C5-75" (Case-finding for Complex Chronic Conditions in Seniors 75+) program, an innovative care model aimed at identifying frailty and commonly associated geriatric conditions among older adults within a Canadian family practice setting and targeting interventions for identified conditions using a feasible, systematic, evidence-informed multi-disciplinary approach. We screen annually for frailty using gait speed and handgrip strength, screen for previously undiagnosed comorbid conditions, and offer frail older adults multi-faceted interventions that identify and address unrecognized medical and psychosocial needs.

Specialist and family physician collaboration: Insights from primary care-based memory clinics.

Given limited available geriatric specialists and complexity of dementia care, there is a need for greater collaboration between primary care and specialists to better meet the needs of persons with dementia. Meaningful family physician-specialist collaboration has the potential to improve health outcomes, timely access to care and more appropriate healthcare resource utilisation. Primary Care Collaborative Memory Clinics (PCCMCs), which include specialist support, provide a significant opportunity for studying the family physician-specialist interface.

SuFEx-based strategies for the preparation of functional particles and cation exchange resins.

A predictable and reproducible number of sulfuric acid sites have been achieved for cation exchange resins by employing a mild SuFEx-based reagent system to effect the hydrolysis of fluorosulfonated polymer beads. The resultant poly(hydrogen sulfate) beads effectively demonstrate their utility as cation exchange resins in ion-capture experiments. Furthermore, their polyfluorosulfonated precursors have also proven to be suitable substrates for traditional SuFEx-type click reactions in both small molecule and protein immobilization applications.

Advanced Care Planning for Persons With Dementia in Primary Care: Attitudes and Barriers Among Health-Care Professionals.

Background: Advance care planning (ACP) provides clarity on goals and preferences for future health-care decisions, the timeliness of which is critical for persons with dementia.

Aim: This study assessed Primary Care Collaborative Memory Clinic (PCCMC) health-care practitioners' desire for more education on ACP, capacity for and attitudes toward ACP, and current ACP practices in their regular family practice and in their PCCMC.

Methods: Primary Care Collaborative Memory Clinic health-care professionals completed a questionnaire in which they rated their interest in learning various ACP-related topics (5-point scale: not at all to very much so), attitudes toward ACP, and the importance of and perceived degree of responsibility for ACP (5-point scale: not at all to extremely).

Ingested Micronizing Plastic Particle Compositions and Size Distributions within Stranded Post-Hatchling Sea Turtles.

From July 2015 to November 2016, 96 post-hatchling sea turtles were collected from 118 km of the Atlantic coastline in Florida, USA, including loggerhead, green, and hawksbill sea turtle species. Forty-five of the recovered turtles were rehabilitated and released, but the remaining 52 died and were frozen. At necropsy, the gastrointestinal tracts of most the turtles contained visible plastic, and collected particles of 27 individuals were chemically characterized by Raman microscopy as polyethylene, polypropylene, polyethylene terephthalate, and polystyrene.

Sialylated Receptor Setting Influences Mycoplasma pneumoniae Attachment and Gliding Motility.

Mycoplasma pneumoniae is a common cause of human respiratory tract infections, including bronchitis and atypical pneumonia. M. pneumoniae binds glycoprotein receptors having terminal sialic acid residues via the P1 adhesin protein.

Biodegradation of Poly(3-hydroxybutyrate- co-3-hydroxyhexanoate) Plastic under Anaerobic Sludge and Aerobic Seawater Conditions: Gas Evolution and Microbial Diversity.

Poly(3-hydroxybutyrate- co-3-hydroxyhexanoate) (poly(3HB- co-3HHx)) thermoplastics are a promising biodegradable alternative to traditional plastics for many consumer applications. Biodegradation measured by gaseous carbon loss of several types of poly(3HB- co-3HHx) plastic was investigated under anaerobic conditions and aerobic seawater environments. Under anaerobic conditions, the biodegradation levels of a manufactured sheet of poly(3HB- co-3HHx) and cellulose powder were not significantly different from one another over 85 days with 77.

Covalent Grafting of Antifouling Phosphorylcholine-Based Copolymers with Antimicrobial Nitric Oxide Releasing Polymers to Enhance Infection-Resistant Properties of Medical Device Coatings.

Medical device coatings that resist protein adhesion and bacterial contamination are highly desirable in the healthcare industry. In this work, an antifouling zwitterionic terpolymer, 2-methacryloyloxyethyl phosphorylcholine-co-butyl methacrylate-co-benzophenone (BPMPC), is covalently grafted to a nitric oxide (NO) releasing antimicrobial biomedical grade copolymer of silicone-polycarbonate-urethane, CarboSil, to significantly enhance the biocompatibility, nonspecific protein repulsion and infection-resistant properties. The NO donor embedded into CarboSil is S-nitroso-N-acetylpenicillamine (SNAP) and covalent grafting of the BPMPC is achieved through rapid UV-cross-linking, providing a stable, hydrophilic coating that has excellent durability over a period of several weeks under physiological conditions.

A multi-defense strategy: Enhancing bactericidal activity of a medical grade polymer with a nitric oxide donor and surface-immobilized quaternary ammonium compound.

Unlabelled: Although the use of biomedical devices in hospital-based care is inevitable, unfortunately, it is also one of the leading causes of the nosocomial infections, and thus demands development of novel antimicrobial materials for medical device fabrication. In the current study, a multi-defense mechanism against Gram-positive and Gram-negative bacteria is demonstrated by combining a nitric oxide (NO) releasing agent with a quaternary ammonium antimicrobial that can be covalently grafted to medical devices. Antibacterial polymeric composites were fabricated by incorporating an NO donor, S-nitroso-N-acetyl-penicillamine (SNAP) in CarboSil® polymer and top coated with surface immobilized benzophenone based quaternary ammonium antimicrobial (BPAM) small molecule.