Publications by authors named "Jan D Hoffmann"
Article Synopsis
- Sleep plays a crucial role in heart health, especially after a heart attack (myocardial infarction), by influencing inflammatory responses and healing processes.
- After a heart attack, certain immune cells (monocytes) are recruited to the brain to promote sleep, which helps reduce harmful stress on the heart and supports recovery.
- Disruption of sleep can worsen heart function and increase the risk of further cardiovascular issues, as poor sleep can reprogram immune cells in a way that enhances inflammation and hinders the healing process.
Glial cells and central nervous system (CNS)-infiltrating leukocytes contribute to multiple sclerosis (MS). However, the networks that govern crosstalk among these ontologically distinct populations remain unclear. Here, we show that, in mice and humans, CNS-resident astrocytes and infiltrating CD44CD4 T cells generated interleukin-3 (IL-3), while microglia and recruited myeloid cells expressed interleukin-3 receptor-ɑ (IL-3Rɑ).
View Article and Find Full Text PDF