Publications by authors named "Jamie D Aquino"
Primary cutaneous squamous cell carcinoma (cSCC) is responsible for ~10,000 deaths annually in the United States. Stratification of risk of poor outcome at initial biopsy would significantly impact clinical decision-making during the initial post operative period where intervention has been shown to be most effective. Using whole-slide images (WSI) from 163 patients from 3 institutions, we developed a self supervised deep-learning model to predict poor outcomes in cSCC patients from histopathological features at initial diagnosis, and validated it using WSI from 563 patients, collected from two other academic institutions.
View Article and Find Full Text PDFAcral melanoma is an aggressive type of melanoma with unknown origins. It is the most common type of melanoma in individuals with dark skin and is notoriously challenging to treat. We examine exome sequencing data of 139 tissue samples, spanning different progression stages, from 37 patients.
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- * The tumors primarily affected younger patients, averaging 20 years old, and typically appeared as small bumps on the ear or extremities, showing specific growth patterns and cellular features under a microscope.
- * Follow-up on these patients indicated a positive outlook, as no recurrences or metastases were observed over a median follow-up period of over 4 years.
Article Synopsis
- - Primary cutaneous squamous cell carcinoma (cSCC) causes around 10,000 deaths each year in the U.S., and assessing the risk of poor outcomes right at the time of initial biopsy can greatly influence clinical decisions.
- - A multi-institutional study introduced a self-supervised deep-learning model that can predict the likelihood of poor outcomes in cSCC, revealing that certain histomorphological features like poor differentiation and deep invasion are linked to worse prognoses.
- - This new model is particularly effective for assessing risk in specific types of cSCC (T2a/T2), which can help identify patients who might need closer monitoring or more aggressive treatment right after diagnosis.
Acral melanoma is an aggressive type of melanoma with unknown origins, arising on the sole, palm, or nail apparatus. It is the most common type of melanoma in individuals with dark skin and is notoriously challenging to treat. Our study examined exome sequencing data from 139 tissue samples, spanning different progression stages, collected from 37 patients.
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