Publications by authors named "James A Abraham"
Article Synopsis
- Elastin is a key component of elastic fibers that affects tendon mechanics, but differences across species and tendon functions, particularly in humans, are not well understood.
- Tendons meant for energy storage contain more elastin than those serving a positional function, with human tendons exhibiting about twice the elastin content of other species.
- Mechanical testing revealed that elastin degradation decreases stress values and alters the stress-strain curve, indicating that fascicular elastic fibers play a crucial role in tendon mechanics, especially in human and energy-storing tendons.
Pleiotropic Effects of Simvastatin and Losartan in Preclinical Models of Post-Traumatic Elbow Contracture.
Front Bioeng Biotechnol
February 2022
Elbow trauma can lead to post-traumatic joint contracture (PTJC), which is characterized by loss of motion associated with capsule/ligament fibrosis and cartilage damage. Unfortunately, current therapies are often unsuccessful or cause complications. This study aimed to determine the effects of prophylactically administered simvastatin (SV) and losartan (LS) in two preclinical models of elbow PTJC: an elbow-specific rat injury model and an collagen gel contraction assay.
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