Weight change and BMI are not prognostic markers of survival outcomes in sacituzumab govitecan therapy for mTNBC in the Polish female cohort.

Background: Body mass index (BMI) and weight change are commonly explored as prognostic factors in breast cancer. However, their impact on outcomes with sacituzumab govitecan (SG) in metastatic triple-negative breast cancer (mTNBC) remains poorly defined.

Objectives: To evaluate the association between baseline BMI, weight change during treatment, and clinical outcomes-including survival and adverse events (AEs)-in a real-world Polish cohort of women with mTNBC receiving SG therapy.

New statistical guidelines for manuscripts submitted to Advances in Clinical and Experimental Medicine.

The updated statistical reporting guidelines for Advances in Clinical and Experimental Medicine (ACEM) streamline the way in which authors describe their statistical analyses and results. In response to the rising popularity of advanced techniques - such as Bayesian statistics and machine learning - the revisions balance methodological rigor with article readability.

The Influence of Anti-PAR 1 and Anti-ACE 2 Antibody Levels on the Course of Specific Glomerulonephritis Types.

Anti-PAR 1 (protease-activated receptor 1) and anti-ACE 2 (angiotensin 2-converting enzyme 2) antibodies are a kind of non-HLA (human leukocyte antigens) antibodies postulated to be of significance in autoimmunological diseases and organ transplantation. We assessed anti-PAR 1 and anti-ACE 2 antibody levels in patients with membranous nephropathy = 18, focal and segmental glomerulosclerosis (FSGS) = 25, lupus nephritis (LN) = 17, IgA nephropathy = 14, mesangial proliferative (non-IgA) glomerulonephritis = 6, c-ANCA (cytoplasmic anti-neutrophil cytoplasmic antibodies) vasculitis = 40, p (perinuclear)-ANCA vasculitis = 16, and compared them with a healthy control group = 22. Next, we observed the clinical course of the patients (creatinine, total protein, and albumin) up to 2 years and correlated the results with the level of antibodies.

The Influence of Anti-ETAR and Anti-CXCR3 Antibody Levels on the Course of Specific Glomerulonephritis Types.

Anti-ETAR (endothelin A receptor) antibodies and anti-CXCR3 (C-X-C motif chemokine receptor 3) antibodies are types of non-HLA (human leukocyte antigens) antibodies that could have some influence on the course of glomerulonephritis. The authors aimed to study the influence of these antibodies' levels on the course of specific glomerulonephritis types. We evaluated the anti-ETAR and anti-CXCR3 antibody levels in the serum of patients with membranous nephropathy (n = 18), focal and segmental glomerulosclerosis (FSGS) (n = 25), systemic lupus erythematosus (n = 17), IgA nephropathy (n = 14), mesangiocapillary glomerulonephritis (n = 6), anti-neutrophil cytoplasmic antibodies (c-ANCA) vasculitis (n = 40), and perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) vasculitis (n = 16), and we compared their levels with the control group (n = 22).

Development of New Predictive Equations for the Resting Metabolic Rate (RMR) of Women with Lipedema.

This study aimed to develop a novel predictive equation for calculating resting metabolic rate (RMR) in women with lipedema. We recruited 119 women diagnosed with lipedema from the Angiology Outpatient Clinic at Wroclaw Medical University, Poland. RMR was assessed using indirect calorimetry, while body composition and anthropometric measurements were conducted using standardized protocols.