Publications by authors named "Jairo Gutierrez"

Older adults make up about 12% of the public sector, primary care, and hospital use and represent a large proportion of the users of healthcare services. Older people are also more vulnerable to serious injury from unexpected falls due to tripping, slipping, or illness. This underscores the immediate necessity of stable and cost-effective e-health technologies in maintaining independent living.

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Recent research suggests that a polygeneric immunogen made from the venoms of the most medically important viperid and elapid snakes in sub-Saharan Africa could elicit a broader antibody response in horses compared to the current EchiTAb-plus-ICP antivenom, especially against neurotoxic elapid venoms. To test this, 25 horses that have been regularly immunized to produce this antivenom were reimmunized with an immunogen containing 22 venoms from various snake species from the genera , , , and both spitting and non-spitting . The plasma collected from these horses was processed using the caprylic acid method to produce an industrial-scale freeze-dried antivenom.

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Article Synopsis
  • - The study evaluated the effectiveness of dynamic body-feed filtration (DBF) in removing bulky solids from equine hyperimmune plasma during snake antivenom production using caprylic acid, comparing various diatomites for optimal filtration performance.
  • - C1000 diatomite yielded the best results at 90 g/L concentration, demonstrating a recovery of immunoglobulins of 108 ± 4% in a scale-up to 50 L batches, while meeting quality specifications for the antivenoms.
  • - Unlike traditional open filtration systems, DBF offers enhanced microbiological safety due to its closed system design and faster filtration process, making it a cost-effective and compliant alternative for primary clarification in antivenom manufacturing.
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Industrial control systems (ICSs), supervisory control and data acquisition (SCADA) systems, and distributed control systems (DCSs) are fundamental components of critical infrastructure (CI). CI supports the operation of transportation and health systems, electric and thermal plants, and water treatment facilities, among others. These infrastructures are not insulated anymore, and their connection to fourth industrial revolution technologies has expanded the attack surface.

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The Internet of Things (IoT) is one of the fastest emerging technologies in the industry. It includes diverse applications with different requirements to provide services to users. Secure, low-powered, and long-range transmissions are some of the most vital requirements in developing IoT applications.

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To supporting a wider and diverse range of applications, device-to-device (D2D) communication is a key enabler in heterogeneous cellular networks (HetCNets). It plays an important role in fulfilling the performance and quality of service (QoS) requirements for 5G networks and beyond. D2D-enabled cellular networks enable user equipment (UE) to communicate directly, without any or with a partial association with base stations (eNBs).

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Article Synopsis
  • In response to the global COVID-19 pandemic, researchers developed two equine-based polyclonal formulations targeting SARS-CoV-2, leveraging long-standing expertise in snake antivenom production.
  • Both formulations, created from horse immunity to specific viral proteins, demonstrated high levels of anti-viral antibodies and substantial efficacy in neutralizing the virus in laboratory tests.
  • The formulations show promise as an alternative therapy for COVID-19, especially in resource-limited settings, though they require further clinical testing to confirm safety and effectiveness.
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Background: Prediabetes and type 2 diabetes mellitus (T2DM) are one of the major long-term health conditions affecting global healthcare delivery. One of the few effective approaches is to actively manage diabetes via a healthy and active lifestyle.

Objectives: This research is focused on early detection of prediabetes and T2DM using wearable technology and Internet-of-Things-based monitoring applications.

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Our goal is to understand the appearance and spread of forms of puerperal insanity in Argentina and Colombia in the late nineteenth and early twentieth century, as well as their decline or disappearance around the 1940s. This is a historical and hermeneutical study, which uses the concepts of "field of visibility" and "ecological niche" for a transitory disease. There was no correlation between pregnancy, childbirth and puerperium and the state of delirium that led to commitment, which was attributed to predisposing factors; furthermore, forms of puerperal insanity were nosographically distinct due to their unique etiopathogeneses.

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To improve the performance of Intensive Care Units (ICUs), the field of bio-statistics has developed scores which try to predict the likelihood of negative outcomes. These help evaluate the effectiveness of treatments and clinical practice, and also help to identify patients with unexpected outcomes. However, they have been shown by several studies to offer sub-optimal performance.

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Worldwide spending on long-term and chronic care conditions is increasing to a point that requires immediate interventions and advancements to reduce the burden of the healthcare cost. This research is focused on early detection of prediabetes and type 2 diabetes mellitus (T2DM) using wearable technology. An artificial intelligence model was developed based on adaptive-neuro fuzzy interference to detect prediabetes and T2DM via individualized monitoring.

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