Publications by authors named "Jade Carruthers"
Data resource profile: Scottish Linked Pregnancy and Baby Dataset (SLiPBD).
Int J Popul Data Sci
May 2025
Introduction: Here we present the Scottish Linked Pregnancy and Baby Dataset (SLiPBD), a new national data resource held by Public Health Scotland (PHS).
Methods: SLiPBD comprises a population-based e-cohort of all fetuses and births (babies) from pregnancies to women in Scotland from 2000 onwards. It is updated monthly by linking and reconciling the following national datasets: antenatal booking records; general and maternity hospital discharge records; termination of pregnancy notifications; and statutory live and stillbirth registrations.
Is the period of austerity in the UK associated with increased rates of adverse birth outcomes?
Eur J Public Health
December 2024
Article Synopsis
- Significant declines in health outcomes have been noted in the UK since the early 2010s, particularly in life expectancy and increased inequalities, largely linked to government austerity measures affecting poorer populations.
- Analysis of live births in Scotland from 1981 to 2019 revealed higher rates of low birthweight (LBW) and preterm births during the austerity period, especially in deprived areas, while small-for-gestational-age rates decreased.
- The study emphasizes urgent attention from the newly elected UK government to address these trends, as they point to serious implications for the health of children and adults linked to economic hardship.
Article Synopsis
- A national study in Scotland examined how SARS-CoV-2 infection and COVID-19 vaccination during pregnancy affect maternal and neonatal health outcomes in women with singleton pregnancies lasting 20 weeks or longer.
- Results showed that SARS-CoV-2 infection is linked to higher risks of preterm births, severe maternal complications, and venous thromboembolism.
- Conversely, the study found no increased risks associated with COVID-19 vaccination, indicating it is a safe choice for pregnant women to help protect themselves and their babies.
Background: Vaccination continues to be the key public health measure for preventing severe COVID-19 outcomes. Certain groups may be at higher risk of incomplete vaccine schedule, which may leave them vulnerable to COVID-19 hospitalisation and death.
Aim: To identify the sociodemographic and clinical predictors for not receiving a scheduled COVID-19 vaccine after previously receiving one.
Background: There are no effective treatments for brain tumor-related fatigue. We studied the feasibility of two novel lifestyle coaching interventions in fatigued brain tumor patients.
Methods: This phase I/feasibility multi-center RCT recruited patients with a clinically stable primary brain tumor and significant fatigue (mean Brief Fatigue Inventory [BFI] score ≥ 4/10).
Evidence on associations between COVID-19 vaccination or SARS-CoV-2 infection and the risk of congenital anomalies is limited. Here we report a national, population-based, matched cohort study using linked electronic health records from Scotland (May 2020-April 2022) to estimate the association between COVID-19 vaccination and, separately, SARS-CoV-2 infection between six weeks pre-conception and 19 weeks and six days gestation and the risk of [1] any major congenital anomaly and [2] any non-genetic major congenital anomaly. Mothers vaccinated in this pregnancy exposure period mostly received an mRNA vaccine (73.
View Article and Find Full Text PDFConfirmed SARS-CoV-2 infection in Scottish neonates 2020-2022: a national, population-based cohort study.
Arch Dis Child Fetal Neonatal Ed
July 2023
Objectives: To examine neonates in Scotland aged 0-27 days with SARS-CoV-2 infection confirmed by viral testing; the risk of confirmed neonatal infection by maternal and infant characteristics; and hospital admissions associated with confirmed neonatal infections.
Design: Population-based cohort study.
Setting And Population: All live births in Scotland, 1 March 2020-31 January 2022.
Article Synopsis
- A national study in Scotland investigated the safety of COVID-19 vaccines in early pregnancy by comparing vaccinated women to unvaccinated controls for their risk of miscarriage and ectopic pregnancy.
- The study included 18,780 women for miscarriage analysis and 10,570 for ectopic pregnancy, finding no significant association between vaccination and either of these outcomes.
- The results support ongoing public health recommendations that COVID-19 vaccination is safe for pregnant women and is the best way to protect themselves and their babies from the virus.
Background: Evidence suggests that the SARS-CoV-2 omicron (B.1·1.529) is associated with lower risks of adverse outcomes than the delta (B.
View Article and Find Full Text PDFBackground: Surgery for renal cell carcinoma (RCC) with venous tumour thrombus (VTT) extension into the renal vein (RV) and/or inferior vena cava (IVC) has high peri-surgical morbidity/mortality. NAXIVA assessed the response of VTT to axitinib, a potent tyrosine kinase inhibitor.
Methods: NAXIVA was a single-arm, multi-centre, Phase 2 study.
Article Synopsis
- There is a lack of comprehensive data on COVID-19 vaccine uptake and infection outcomes specifically in pregnant women.
- In Scotland, 25,917 COVID-19 vaccinations were administered to 18,457 pregnant women from December 2020 to October 2021, with only 32.3% of those giving birth in October 2021 being fully vaccinated compared to 77.4% in the general female population aged 18-44.
- Unvaccinated pregnant women showed significantly higher risks of severe outcomes: 77.4% of SARS-CoV-2 infections, 90.9% of hospital admissions, and 98% of critical care admissions occurred in this group, highlighting the urgent need to improve vaccination