Obstructive Sleep Apnea in Adult Dialysis Patients: A Review.

Obstructive sleep apnea (OSA) is an extremely common but underdiagnosed problem in adults receiving dialysis therapy. Patients with end-stage kidney disease (ESKD) on hemodialysis or peritoneal dialysis have a higher prevalence of OSA compared to the general population (1-3). This condition carries significant clinical implications, contributing to impaired sleep quality, daytime fatigue, and elevated cardiovascular risk if left untreated (4,5).

Gelatinous pleural effusion in advanced lung adenocarcinoma: a case report.

Background: Gelatinous pleural effusions, a rare subtype of exudative effusions with elevated viscosity due to high hyaluronic acid levels, are often associated with malignancies, particularly malignant pleural mesothelioma and some metastatic cancers. Such effusions present unique challenges in both diagnosis and management due to their thickness, which complicates drainage using standard techniques. This case highlights the clinical significance of recognizing unusual pleural fluid characteristics and employing advanced drainage interventions, particularly in metastatic lung adenocarcinoma.

PhysOnline: An Open Source Machine Learning Pipeline for Real-Time Analysis of Streaming Physiological Waveform.

Real-time analysis of streaming physiological data to identify earlier abnormal conditions is an important aspect of precision medicine. However, open-source systems supporting this workflow are lacking. In this paper, we present PhysOnline, a pipeline built on the open-source Apache Spark platform to ingest streaming physiological data for online feature extraction and machine learning.

Linezolid-induced serotonin toxicity in a patient not taking monoamine oxidase inhibitors or serotonin receptor antagonists.

Linezolid is an oxazolidinone antibiotic with weak monoamine oxidase (MAO) type A and MAO type B inhibitory effects. Linezolid has been associated with serotonin toxicity when used concomitantly with multiple medications that are known to increase serotonin concentrations. We report the case of a 65-year-old woman with signs and symptoms of serotonin toxicity following administration of linezolid for treatment of methicillin-resistant Staphylococcus aureus pneumonia.