Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis.

Long-term exercise training elicits tremendous health benefits; however, the molecular understanding is incomplete and identifying therapeutic targets has been challenging. Rho GTPases are among the most regulated groups of proteins after exercise in human skeletal muscle, yet, unexplored candidates for mediating the effects of exercise training. We found that the Rho GTPase Rac1 was activated acutely after multiple exercise modalities in human skeletal muscle.

Total Hip Arthroplasty versus Education and Exercise: A Secondary Analysis of Propensity Matched Data Comparing Outcomes Across Hip Osteoarthritis Symptom Severity.

Background: Using propensity-matched data, we have previously shown that total hip arthroplasty (THA) provides superior outcomes to an education and exercise (Edu + Ex) program in patients who have hip osteoarthritis (OA), overall. This study investigated whether treatment effects of Edu + Ex versus THA differ across patients who have varying degrees of hip OA symptom severity.

Methods: This was a secondary analysis of propensity-matched patients who had hip OA who underwent THA or an Edu + Ex program (1:1 match ratio).

Design Ideas for Inpatient Stroke Rehabilitation Facilities: Living Lab Findings.

ObjectivesTo provide actionable, co-designed ideas for how to optimize the built environment and service of inpatient stroke rehabilitation facilities.BackgroundInput from diverse stakeholders is needed to ensure that stroke rehabilitation spaces address the unique learning and practice needs of users. In this paper, we report the first phase of the Neuroscience Optimized Virtual Environments Living Lab (NOVELL) Redesign project.

i-REBOUND Cook Well After Stroke: Co-Designing a Culinary Nutrition Programme for Australian Stroke Survivors.

Introduction: Stroke is a life-altering event for survivors. While improving diet quality is associated with reduced stroke risk, the post-stroke effects often make meal preparation difficult. There is a lack of published research on culinary nutrition programmes tailored to stroke survivors' recovery journey.