Publications by authors named "J Patrizia Stohn"
Social isolation stress has numerous known negative health effects, including increased risk for cardiovascular disease, dementia, as well as overall mortality. The impacts of social isolation on skeletal health, however, have not been thoroughly investigated. We previously found that 4 wk of social isolation through single housing led to a significant reduction in trabecular and cortical bone in male, but not female, mice.
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- Social isolation stress negatively impacts health, increasing risks for cardiovascular disease, dementia, and overall mortality, with less known effects on bone health.
- A study found that male mice housed alone experienced significant bone loss over four weeks, but attempts to mitigate this loss by keeping them at a warmer temperature did not yield the expected results.
- The research indicates that social isolation affects bone health through mechanisms other than thermal stress, suggesting a complex relationship between social isolation and skeletal health that warrants further investigation.
Calorie restriction (CR) can lead to weight loss and decreased substrate availability for bone cells. Ultimately, this can lead to impaired peak bone acquisition in children and adolescence and bone loss in adults. But the mechanisms that drive diet-induced bone loss in humans are not well characterized.
View Article and Find Full Text PDFGenetic mutations identified in genome-wide association studies can only explain a small percentage of the cases of complex, highly heritable human conditions, including neurological and neurodevelopmental disorders. This suggests that intergenerational epigenetic effects, possibly triggered by environmental circumstances, may contribute to their etiology. We previously described altered DNA methylation signatures in the sperm of mice that experienced developmental overexposure to thyroid hormones as a result of a genetic defect in hormone clearance (DIO3 deficiency).
View Article and Find Full Text PDFMesoderm specific transcript (Mest)/paternally expressed gene-1 (Peg1) is an imprinted gene expressed predominantly from the paternal allele. Aberrations in maternal behavior were previously reported in a Mest global knockout mouse (Mesttm1Masu). In this study, we performed in-depth social and maternal behavioral testing in a mouse model of Mest inactivation developed in our laboratory (Mesttm1.
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