Advanced vascular ultrasound prior to radial artery cannulation on the intensive care unit: A feasibility service evaluation.

Background: Radial arterial catheters are frequently used for monitoring and blood sampling in critical care patients. Ischaemic complications are rare but can cause significant morbidity. The use of vascular ultrasound in critical care is becoming increasingly commonplace.

Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays.

The NLRP3 (NOD-like receptor family, pyrin domain-containing protein 3) inflammasome, a multiprotein complex, plays a crucial role in triggering the release of pro-inflammatory cytokines like interleukin-1 beta. Abnormal activation of NLRP3 can mediate an aberrant immune response to viral infections and is associated with inflammatory diseases. In this study, the goal was to identify bioactive, potent, and specific inhibitors of NLRP3 that could modulate the inflammasome pathway and assess their potential therapeutic relevance.

Bridging the gap in mental health literacy: co-adapting and feasibility testing a digital intervention to improve mental health literacy amongst young people aged 12-14 in the UK.

Background: Digital interventions have shown promise in enhancing mental health literacy among young people (YP). Initially developed in Indonesia, the Improving Mental Health Literacy Among Young People in Indonesia (IMPeTUs) intervention is a co-produced digital application designed to improve mental health literacy and self-management of anxiety and depression in YP. This study aimed to co-adapt the IMPeTUs intervention with YP in the UK and evaluate the feasibility of conducting a future definitive trial in education and community settings.

Toward a synthesis of Paleoamerican fluted point cultures in the Carolinas.

Synthesizing data gathered from private and institutional Paleoamerican artifact collections over the last 50 years, this study examines the typological classification and spatial distributions of 375 fluted points from North Carolina. Clovis, Redstone, and Cumberland points are typologically characterized and differentiated. Landmark Geometric Morphometric (LGM) analyses suggest that North Carolina Clovis points are significantly different in shape than Western Clovis points, consistent with conclusions about continental Clovis variation.

Search for Quasiparticle Scattering in the Quark-Gluon Plasma with Jet Splittings in pp and Pb-Pb Collisions at sqrt[s_{NN}]=5.02 TeV.

The ALICE Collaboration reports measurements of the large relative transverse momentum (k_{T}) component of jet substructure in pp and Pb-Pb collisions at center-of-mass energy per nucleon pair sqrt[s_{NN}]=5.02  TeV. Enhancement in the yield of such large-k_{T} emissions in head-on Pb-Pb collisions is predicted to arise from partonic scattering with quasiparticles of the quark-gluon plasma.