ATP synthase subunit γ mediates Cry1Ac binding and toxicity in Grapholita molesta.

The insect midgut peritrophic membrane (PM) plays important roles in insect-microbe interactions. Bacillus thuringiensis (Bt) and its proteinaceous toxins are widely used for insect control. To understand the role of PM in insects against Bt toxins, this study selected Grapholita molesta Busck (Lepidoptera: Tortricidae), a worldwide pest infesting fruit trees, as the research subject.

Moh1 coordinates ROS-dependent apoptosis in genotoxic stress response of Candida albicans.

Candida albicans employs apoptosis to maintain genomic stability under genotoxic stress, yet its regulatory mechanisms remain poorly defined. Here, we characterize the role of a putative pro-apoptotic factor Moh1 in C. albicans.

Identification of a Pseudomonas brassicacearum strain as a potential biocontrol agent against clubroot in cruciferous plants through endophytic bacterial community analysis and culture-dependent isolation.

Background: Clubroot, caused by Plasmodiophora brassicae, significantly impacts cruciferous crop production worldwide. Biocontrol is an environmentally friendly and promising approach for clubroot management. Endophytic bacteria are known for their ability to promote plant growth and induce resistance against plant diseases.

Targeting O-GlcNAcylated METTL3 impedes MDS/AML progression via diminishing SRSF1 mA modification.

N6-methyladenosine (mA) modification, primarily regulated by methyltransferase-like protein 3 (METTL3), plays a pivotal role in RNA metabolism and leukemogenesis. However, the post-translational mechanisms governing METTL3 stability and function remain incompletely understood. Given the widespread occurrence of O-GlcNAcylation on nuclear and cytosolic proteins, we hypothesized that METTL3 might undergo O-GlcNAcylation, thereby influencing its stability and oncogenic function in myeloid malignancies.

Exosome-mediated co-delivery of superoxide dismutase and chondroitinase ABC for multiple sclerosis therapy.

Multiple sclerosis is an autoimmune demyelinating disease, and its effective treatment is a great challenge. As a typical animal model for studying multiple sclerosis, experimental autoimmune encephalomyelitis (EAE) is characterized by inflammation, demyelination, gliosis and axonal loss. Thus, simultaneous regulation of neuroinflammation and remyelination may be a useful strategy against EAE.