CD371-Targeted CAR T cells Secreting Interleukin-18 Exhibit Robust Expansion and Clear Refractory Acute Myeloid Leukemia.

Success of chimeric antigen receptor (CAR) T-cell therapy in lymphoid malignancies has not yet been recapitulated in acute myeloid leukemia (AML). We developed CAR T-cells targeting CD371 with a mutated CD28 costimulatory domain to limit T-cell exhaustion, and constitutive interleukin-18 secretion to enhance immune function (CD371/SAVVY/IL-18 CAR). We initiated a phase I trial (NCT06017258), successfully manufactured and administered CD371/SAVVY/IL-18 CAR T-cells in 5 patients with relapsed/refractory AML and observed expansion following a single infusion of 3x104 or 3x105 CAR T-cells/kg; three patients refractory to ≥5 lines of therapy and post-allogeneic transplant exhibited AML clearance and no evidence of graft-versus-host disease.

Targeted Therapies and Immunotherapies for Diffuse Large B-Cell Lymphoma.

Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma (NHL) [...

Mucosal boosting increases protective efficacy of an influenza vaccine in mice.

Influenza virus infection is a significant cause of global mortality. However, the development of influenza vaccines that induce robust immune responses at the site of respiratory mucosal exposure has proven challenging. Here, we assessed immune responses and protective efficacy of a rhesus adenovirus serotype 52 (RhAd52) vectored influenza vaccine encoding the hemagglutinin (HA) glycoprotein from A/California/07/2009 administrated by systemic or mucosal routes of immunization.

Unusual Presentation of Streptococcus uberis Bacteremia in a Complex Patient: A Case Report.

, primarily recognized as a pathogen in bovine mastitis, rarely causes infections in humans. Here, we present a case of bacteremia in a 58-year-old male patient with multiple comorbidities, including end-stage renal disease (ESRD) on hemodialysis, type 2 diabetes mellitus, and a history of tricuspid valve endocarditis. The patient presented with generalized weakness, fatigue, and diarrhea, alongside intermittent chills and elevated heart rate during hemodialysis.

Structural Investigation and Enriched Catalysis of Cu-Complex-Encapsulated Microporous Catalyst with Pragmatic Modeling for Prediction of Activity by Using Machine Learning.

Silicoaluminophosphates (SAPOs) are structurally diverse materials widely used in separation, catalysis, and environmental applications. In this study, a simple post-synthetic method is used to create a hybrid porous material by immobilizing a copper(II) complex onto base-functionalized SAPO molecular sieves. The copper complex, synthesized using 2,9-dimethyl-1,10-phenanthroline and copper nitrate, is structurally confirmed through single-crystal X-ray diffraction.