Publications by authors named "Isabelle S R Storer"
Article Synopsis
- * Researchers created a library of 111 genetically modified Aspergillus fumigatus mutants to identify important antifungal targets, discovering that a specific kinase, YakA, is crucial for regulating susceptibility to azoles and pathogenicity.
- * The study found that inhibiting YakA not only weakens the fungus's ability to grow and invade tissues but also enhances the effectiveness of azoles when combined with a compound (1-ECBC), suggesting a potential avenue for improving treatment.
Widespread use of azole antifungals in agriculture has been linked to resistance in the pathogenic fungus Aspergillus fumigatus. We show that exposure of A. fumigatus to the agrochemical fungicide, ipflufenoquin, in vitro can select for strains that are resistant to olorofim, a first-in-class clinical antifungal with the same mechanism of action.
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- Fungal infections are prevalent in HIV-infected individuals in Africa and are a significant cause of mortality, often going undiagnosed.
- A scoping review of autopsy studies from 1991 to 2019 identified a total of 13,066 HIV-infected individuals across ten African countries, revealing that 36.7% of identified pathogens were fungal.
- The most common fungal pathogens were Cryptococcus species (28.0%), and invasive fungal infections were present in more than one-third of those who died from HIV, highlighting the need for improved diagnosis and treatment.
Aspergillosis, in its various manifestations, is a major cause of morbidity and mortality. Very few classes of antifungal drugs have been approved for clinical use to treat these diseases and resistance to the first-line therapeutic class, the triazoles are increasing. A new class of antifungals that target pyrimidine biosynthesis, the orotomides, are currently in development with the first compound in this class, olorofim in late-stage clinical trials.
View Article and Find Full Text PDFFungal diseases are a serious health burden worldwide with drug resistance compromising efficacy of the limited arsenal of antifungals available. New drugs with novel mechanisms of action are desperately needed to overcome current challenges. The screening of the genome identified 35 phosphatases, four of which were previously reported as essential for viability.
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