Diagnostic Accuracy of Ultrasonography for Detecting Posterior Ligamentous Complex Injuries of Thoracolumbar Trauma: An Updated Systematic Review With Meta-Analysis.

Study DesignSystematic review with meta-analysis.ObjectiveThis study aimed to assess the diagnostic accuracy of USG for detecting PLC injuries.MethodsA systematic search was conducted in PubMed, EMBASE, and Web of Science.

Efficacy, Immunogenicity, Safety, and Tolerability of AADvac1 in Alzheimer Disease: A Systematic Review and Meta-Analysis of Placebo-Controlled Trials.

Background: This systematic review and meta-analysis aimed to evaluate the efficacy, humoral immunogenicity, safety, and tolerability of AADvac1 an active tau-targeted immunotherapy in patients with Alzheimer disease (AD) confirmed by amyloid and tau pathology.

Methods: We searched MEDLINE, Embase, Scopus, and CENTRAL from inception to March 2025 for randomized placebo-controlled trials assessing AADvac1 in AD. Eligible studies included adult patients with biomarker-confirmed AD.

Efficacy and ε4-stratified risk of donanemab in Alzheimer's disease: A systematic review and meta-analysis of randomized clinical trials.

BackgroundDonanemab, a monoclonal antibody targeting amyloid-β (Aβ) plaques, has shown the ability to reduce cerebral amyloid burden in early Alzheimer's disease (AD). However, uncertainties remain regarding its clinical relevance, particularly in relation to tau pathology, ε4 genotype, and methodological limitations in existing trials.ObjectiveTo conduct a systematic review and exploratory meta-analysis to evaluate the efficacy, safety, and tolerability of donanemab in patients with mild to moderate AD.

Machine learning models for predicting therapeutic response in drug-resistant epilepsy: A bivariate diagnostic meta-analysis.

Background: Epilepsy affects approximately 6.4 per 1000 individuals worldwide. Despite advances in antiseizure medications (ASMs), nearly one-third of patients remain refractory to treatment, meeting criteria for drug-resistant epilepsy (DRE).

Blinatumomab Versus Chemotherapy for Post-Induction Consolidation in First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Background: Relapsed B-cell acute lymphoblastic leukemia (B-ALL) remains a therapeutic challenge, particularly in children, adolescents, and young adults. Blinatumomab, a bispecific T-cell engager targeting CD19-positive leukemic cells, has emerged as an alternative to conventional chemotherapy in post-induction consolidation. This meta-analysis aimed to evaluate its impact on survival outcomes, relapse rates, and treatment-related toxicities.

Accuracy of CT Scan for Detecting Posterior Ligamentous Complex Injury in Traumatic Thoracolumbar Fractures: A Systematic Review and Meta-Analysis.

Study DesignA systematic review and meta-analysis.ObjectivesThis systematic review and meta-analysis aim to evaluate the diagnostic accuracy of CT in detecting PLC injuries in traumatic thoracolumbar fractures.MethodsA comprehensive search of PubMed/MEDLINE, Embase, and Web of Science was conducted up to January 2025.

Ocular complications in psoriatic patients: a systematic review and meta-analysis.

Purpose: To assess the prevalence of ocular findings in patients with psoriasis and compare the odds of developing these conditions between the psoriatic and control population through a systematic review and meta-analysis.

Methods: A comprehensive literature search was conducted using PubMed, Embase, Cochrane, and Web of Science databases to identify studies reporting ocular findings in psoriasis patients. Inclusion criteria encompassed cross-sectional, case-control, cohort studies, case series, and case studies.