Publications by authors named "Isabelle L Jones"
Mycobacterium tuberculosis (Mtb) remains the world's deadliest bacterial pathogen. There is an urgent medical need to develop new drugs that shorten the treatment duration to combat widespread multi-drug-resistant and extensive-drug-resistant Mtb. Here, we present a preclinical covalent compound, CMX410, that contains an aryl fluorosulfate (SuFEx) warhead and uniquely targets the acyltransferase domain of Pks13, an essential enzyme in cell-wall biosynthesis.
View Article and Find Full Text PDFArticle Synopsis
- Scientists created new medicines called spectinamides to help treat tuberculosis (TB) more effectively.
- One of these, named MBX-4888A, works well with other TB drugs like rifampin and pyrazinamide in mice.
- The research showed that using MBX-4888A can help shorten the treatment time for TB and seems to be safe for long-term use in mice.
Article Synopsis
- Spectinamides are new medicines that help fight TB (tuberculosis), modified to work better in the body.
- In studies with mice, one type called MBX-4888A showed it could improve treatment when used with other TB drugs.
- This research tested how well it works in different mouse models, showing it's safe and might help cure TB faster.