SCORE2-Older Persons (SCORE2-OP): Validation and Added Value of Excessive Daytime Sleepiness in a French Cohort.

Background: Cardiovascular diseases are the leading cause of death worldwide, particularly in older adults. While the Systematic Coronary Risk Evaluation 2-Older Persons (SCORE2-OP) model estimates 10-year cardiovascular risk in this population, its validation in general European cohorts remains limited. Given growing relationships between sleep disturbances and cardiovascular risk, we aimed to validate SCORE2-OP in a French cohort and assess the incremental value of excessive daytime sleepiness (EDS).

16-mer hypocretin-1/orexin-A in cerebrospinal fluid to diagnose narcolepsy.

Study Objectives: Cerebrospinal fluid (CSF) hypocretin-1/orexin-A quantification via radioimmunoassay (RIA) is used for diagnosing narcolepsy type 1(NT1), but its limitations require alternative methods. Using liquid chromatography-mass spectrometry (LC-MS), this study aimed to 1/fully characterize CSF orexin-A fragments detected by the gold standard RIA method, and 2/assess diagnostic relevance of measuring the most prevalent fragment, a 16-mer, in patients with NT1, narcolepsy type 2(NT2), idiopathic hypersomnia (IH) and non-specified hypersomnolence (NSH).

Methods: CSF samples were analyzed using RIA and LC-MS in patients with hypersomnolence disorders evaluated at the French Narcolepsy National Reference Center.

Systematic Assessment of Dysexecutive Syndrome, Hypersomnolence and Dysautonomia in Kleine-Levin Syndrome.

Background: Kleine-Levin Syndrome (KLS) is a neurological disorder of unknown pathophysiology. It is characterized by relapsing-remitting episodes of hypersomnia, with cognitive symptoms and behavioral disturbances. The diagnosis relies on clinical criteria, which require further standardization.

Efficacy and Safety of Sodium Oxybate in Adults With Idiopathic Hypersomnia: A Randomized Controlled Trial.

Background And Objectives: Idiopathic hypersomnia (IH) is a rare central disorder of hypersomnolence characterized by excessive daytime sleepiness, prolonged nighttime sleep, and sleep inertia. Low-sodium oxybate is the sole Food and Drug Administration-approved treatment for IH. Objective measures of nighttime sleep and daytime sleepiness are lacking with oxybates in IH.

Reproduction life related Kleine-Levin syndrome.

Menstrual-related Kleine-Levin syndrome is characterized by recurrent episodes of hypersomnolence exclusively associated with menstruation, occurring just before or during menses. However, the literature shows that these episodes may also be associated with other events of the reproduction life, namely menarche, ovulation, pregnancy, delivery and menopause. Altogether, we identified 33 cases of reproduction life-related Kleine-Levin syndrome in the world literature.

Sex effect on disease characteristics in patients with narcolepsy type 1.

Study Objectives: Narcolepsy type 1 (NT1) is a rare sleep disorder caused by orexin/hypocretin (Hcrt-1) deficiency, equally prevalent in women and men. Sex differences have been reported in animal models, particularly regarding cataplexy. Whether these differences can be transposed to humans remains unclear.

Insomnia, early and late rising are associated with small hippocampal volume and large white matter hyperintensity burden.

Background: Sleep disturbances have been associated with an increased risk of dementia. The mechanisms remain unclear, although neurodegenerative and vascular pathways are potentially involved. Hence, our study aims to investigate the relationships between several clinical sleep and polysomnographic features and volumes of hippocampus (indicative of neurodegeneration) and white matter hyperintensities (WMH) (reflecting vascular processes).

Clinical and objective correlates of disrupted nighttime sleep in pediatric narcolepsy type 1.

Objectives: Disrupted nocturnal sleep (DNS) is a common symptom in Narcolepsy type 1 (NT1) but remains understudied in pediatric populations. We aimed to identify factors associated with DNS complaint in children with NT1, and to evaluate treatment effect on this symptom.

Methods: Eighty-seven consecutive NT1 children (14 ± 2.

Association of Sleep Disruption With Daytime Sleepiness in Patients With Restless Legs Syndrome.

Background And Objectives: Patients with restless legs syndrome (RLS) often complain of nighttime hyperarousal which can be severe. Whether nocturnal hyperarousal is associated with excessive daytime sleepiness (EDS) remains understudied. This study aimed to compare the frequencies of self-reported and objective EDS between patients with RLS and controls, and to identify factors associated with EDS.

Kleine-Levin syndrome. Clinical boarderlands based on a thorough analysis of 475 case reports.

Objective/background: Kleine-Levin syndrome (KLS) is a rare sleep disorder characterized by recurrent episodes of severe hypersomnolence in association with various degrees of cognitive impairment, perceptive abnormalities, apathy, behavioral disturbances. Some of these symptoms, hypersomnolence, compulsive eating and increased sexual drive may be replaced by their opposites or alternate with them. Remarkably enough, these « atypical symptoms » have never been enlighted nor compared in frequency with corresponding typical symptoms.

Narcolepsy Severity Scale-2 and Idiopathic Hypersomnia Severity Scale to better quantify symptoms severity and consequences in Narcolepsy type 2.

Study Objectives: Narcolepsy type 2 (NT2) is an understudied central disorder of hypersomnolence sharing some similarities with narcolepsy type 1 and idiopathic hypersomnia (IH). We aimed: (1) to assess systematically the symptoms in patients with NT2, with self-reported questionnaires: Epworth Sleepiness Scale (ESS), Narcolepsy Severity Scale (NSS), IH Severity Scale (IHSS), and (2) to evaluate the responsiveness of these scales to treatment.

Methods: One hundred and nine patients with NT2 (31.

The role of cardiovascular health and vascular events in the relationship between excessive daytime sleepiness and dementia risk.

Many studies suggest a relationship between excessive daytime sleepiness (EDS) and dementia incidence, but the underlying mechanisms remain uncertain. The study aimed to investigate the role of cardiovascular burden in the relationship between EDS and dementia incidence over a 12-year follow-up in community-dwelling older adults. We performed analyses on 6171 subjects (aged ≥65 years) free of dementia and vascular disease at baseline.

Brain-derived neurotrophic factor (BDNF) variants and promoter I methylation are associated with prolonged nocturnal awakenings in older adults.

Brain-derived neurotrophic factor (BDNF) is important for sleep physiology. This study investigates whether BDNF variants and promoter I methylation may be implicated in sleep disturbances in older adults. Genotyping was performed for seven BDNF single nucleotide polymorphisms (SNPs) in 355 community-dwelling older adults (aged ≥65 years) and BDNF exon 1 promoter methylation was measured in blood samples at baseline (n = 153).

Cognitive strategies to improve symptoms of restless legs syndrome.

Symptoms of restless legs syndrome are relieved by movement. Whether a cognitive task decreases sensory discomfort remains understudied. We aimed to assess the frequency of patients with restless legs syndrome who report decreased sensory discomfort during cognitive activities, and quantify this decrease during a cognitive task.

Impact of Obstructive Sleep Apnea Syndrome on Ventricular Remodeling after Acute Myocardial Infarction: A Proof-of-Concept Study.

Background: Obstructive sleep apnea syndrome (OSA) is common in patients with acute myocardial infarction (AMI). Whether OSA impacts on the ventricular remodeling post-AMI remains unclear. We compared cardiac ventricular remodeling in patients assessed by cardiac magnetic resonance (CMR) imaging at baseline and six months after AMI based on the presence and severity of OSA.

Rapid eye movement sleep duration during the multiple sleep latency test to diagnose hypocretin-deficient narcolepsy.

Study Objectives: To assess the performances of alternative measures of the multiple sleep latency test (MSLT) to identify hypocretin-deficiency in patients with a complaint of hypersomnolence, including patients with narcolepsy.

Methods: MSLT parameters from 374 drug-free patients with hypersomnolence, with complete clinical and polysomnographic (PSG) assessment and cerebrospinal hypocretin-1 measurement were collected. Conventional (sleep latency, number of sleep onset REM-SOREM-periods) and alternative (sleep duration, REM sleep latency and duration, sleep stage transitions) MSLT measures were compared as function of hypocretin-1 levels (≤110 vs > 110 pg/mL).

Trajectories of sleep duration and timing before dementia: a 14-year follow-up study.

Background: given the complex relationship between sleep and neurodegenerative processes, it is important to examine whether changes in sleep patterns occur prior or close to dementia onset.

Objective: to examine the relationship between sleep parameters and dementia incidence and, to characterize trajectories of sleep patterns before dementia diagnosis.

Design: a 14-year longitudinal study including a nested case-control study.