Publications by authors named "Isabelle C Roseto"
BACKGROUNDPersistent controllers (PCs) maintain antiretroviral-free HIV-1 control indefinitely over time, while transient controllers (TCs) eventually lose virological control. It is essential to characterize the quality of the HIV reservoir in terms of these phenotypes in order to identify the factors that lead to HIV progression and to open new avenues toward an HIV cure.METHODSThe characterization of HIV-1 reservoir from peripheral blood mononuclear cells was performed using next-generation sequencing techniques, such as full-length individual and matched integration site proviral sequencing (FLIP-Seq; MIP-Seq).
View Article and Find Full Text PDFProgressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy.
Cell Host Microbe
January 2023
Article Synopsis
- HIV-1 creates a long-lasting reservoir of infected cells that can't be fully eradicated by antiretroviral therapy (ART), leading to a unique profile in those on long-term treatment.
- Research found that long-term ART-treated individuals had intact proviruses mainly located in heterochromatin regions, especially near centromeres, suggesting a selection process that favors these positions for viral persistence.
- This preferential integration in repressive chromatin may result in a reservoir that is less likely to cause viral rebound if ART is interrupted, indicating a potential mechanism of deep latency in HIV-1.