Use of Brazilian flora as the main source of new antimalarials: a systematic review.

Plants represent an important source of compounds for treating malaria, highlighting the rich biodiversity of Brazilian flora as a vital resource for developing new, effective antimalarial drugs. The present study sought to shed light on the search for new compounds with antimalarial activity obtained from the Brazilian flora. In this sense, a systematic review was conducted using screening techniques based on "The Preferred Reporting Items for Systematic Reviews and Meta-Analysis" (PRISMA) protocol.

Immunogenicity of Vir14-derived peptides to improve the serological diagnosis of infection.

Introduction: Malaria, caused by , remains a major global health problem, particularly in tropical and subtropical regions. This study aimed to investigate the potential of Vir14-derived peptides to improve diagnostic accuracy for infections.

Methods: The reactivity of specific Vir14-derived peptides against sera from acutely infected individuals from endemic and non-endemic areas experiencing a malaria outbreak was assessed, as well as their sensitivity, specificity, and immunodominance.

Arginine-Biofunctionalized Ternary Hydrogel Scaffolds of Carboxymethyl Cellulose-Chitosan-Polyvinyl Alcohol to Deliver Cell Therapy for Wound Healing.

Wound healing is important for skin after deep injuries or burns, which can lead to hospitalization, long-term morbidity, and mortality. In this field, tissue-engineered skin substitutes have therapy potential to assist in the treatment of acute and chronic skin wounds, where many requirements are still unmet. Hence, in this study, a novel type of biocompatible ternary polymer hybrid hydrogel scaffold was designed and produced through an entirely eco-friendly aqueous process composed of carboxymethyl cellulose, chitosan, and polyvinyl alcohol and chemically cross-linked by citric acid, forming three-dimensional (3D) matrices, which were biofunctionalized with L-arginine (L-Arg) to enhance cellular adhesion.

Analyzing Spatial Patterns of Health Vulnerability to Drought in the Brazilian Semiarid Region.

Health determinants might play an important role in shaping the impacts related to long-term disasters such as droughts. Understanding their distribution in populated dry regions may help to map vulnerabilities and set coping strategies for current and future threats to human health. The aim of the study was to identify the most vulnerable municipalities of the Brazilian semiarid region when it comes to the relationship between drought, health, and their determinants using a multidimensional index.

Mapping human vulnerability to climate change in the Brazilian Amazon: The construction of a municipal vulnerability index.

Vulnerability, understood as the propensity to be adversely affected, has attained importance in the context of climate change by helping to understand what makes populations and territories predisposed to its impacts. Conditions of vulnerability may vary depending on the characteristics of each territory studied-social, environmental, infrastructural, public policies, among others. Thus, the present study aimed to evaluate what makes the municipalities of the state of Amazonas, Brazil, vulnerable to climate change in the context of the largest tropical forest in the world, and which regions of the State are the most susceptible.