Publications by authors named "Isabel R Murray"
Article Synopsis
- Head and neck squamous cell carcinomas (HNSCC) have high treatment-related complications and poor survival rates, particularly in recurrent or metastatic cases, with PD-1/PD-L1 inhibitors now being a primary treatment option.
- A study identified 335 genes that enhance PD-L1 expression in HNSCC cells, validating five specific genes (FGF6, IL17A, CD300C, KLR1C, NFKBIA) as key drivers, with FGF ligand being a significant factor in this regulation.
- The research suggests that FGF signaling promotes immune evasion through PD-L1 upregulation, indicating potential for new combination therapies to improve treatment effectiveness against
Microbe-Mediated Activation of Toll-like Receptor 2 Drives PDL1 Expression in HNSCC.
Cancers (Basel)
September 2021
As immunotherapies targeting the PDL1 checkpoint have become a mainstay of treatment for a subset of head and neck squamous cell carcinoma (HNSCC) patients, a detailed understanding of the mechanisms underlying PDL1-mediated immune evasion is needed. To elucidate factors regulating expression of PDL1 in HNSCC cells, a genome-wide CRISPR profiling approach was implemented to identify genes and pathways conferring altered PDL1 expression in an HNSCC cell line model. Our screen nominated several candidate PDL1 drivers, including Toll-like Receptor 2 (TLR2).
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