Publications by authors named "Isabel M Serrano"
Article Synopsis
- * In a study of aged and young mice, researchers analyzed around 2.5 million mitochondrial genomes, revealing unique mutation patterns and high mutation frequency at key replication sites.
- * The findings highlight a difference in mutation types between rodents and primates, with specific mutations showing signs of negative selection, suggesting that mitochondrial genomes adapt and change throughout an organism's life.
Mitochondrial genomes co-evolve with the nuclear genome over evolutionary timescales and are shaped by selection in the female germline. Here, we investigate how mismatching between nuclear and mitochondrial ancestry impacts the somatic evolution of the mt-genome in different tissues throughout aging. We used ultra-sensitive Duplex Sequencing to profile ~2.
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