Publications by authors named "Isabel Everard"
Article Synopsis
- - Bacterial cancer therapy (BCT) using a modified strain of Salmonella (STmΔaroA) shows effectiveness in treating solid tumors, particularly in mouse models of intestinal cancer, by significantly reducing tumor burden and load.
- - The study found that STmΔaroA affects tumor biology by altering the expression of genes related to tumor stemness, epithelial-mesenchymal transition, and the cell cycle, indicating it targets the tumor epithelium actively.
- - Metabolomic analysis revealed that STmΔaroA changes the metabolic environment of tumors, suggesting it competes with the tumor for resources and requires the presence of live bacteria to exert its effects.
Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling.
Mathias Wendt
,
Rosa Bellavita
,
Alan Gerber
,
Nina-Louisa Efrém
,
Thirza van Ramshorst
,
Isabel Everard
Angew Chem Int Ed Engl
June 2021
Protein complexes are defined by the three-dimensional structure of participating binding partners. Knowledge about these structures can facilitate the design of peptidomimetics which have been applied for example, as inhibitors of protein-protein interactions (PPIs). Even though β-sheets participate widely in PPIs, they have only rarely served as the basis for peptidomimetic PPI inhibitors, in particular when addressing intracellular targets.
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