Reestablishment of the Brown Dog Tick Rhipicephalus sanguineus (s.l.) in Chișinău, Moldova: A Case of Indoor Infestation.

The brown dog tick (Rhipicephalus sanguineus sensu lato) is the most widespread tick in the world and a well-recognized vector of numerous pathogens affecting dogs and occasionally humans. This tick is highly adapted to living in human dwellings and can remain active year-round even in some temperate regions. Due to its ability to reproduce indoors, R.

Thiosemicarbazone-Based Compounds: Cancer Cell Inhibitors with Antioxidant Properties.

Thiosemicarbazone-based compounds have attracted significant attention in recent years due to their potential as inhibitors of cancer cell proliferation. They not only exhibit strong antiproliferative effects but also possess antioxidant properties that are crucial in combating oxidative stress linked to cancer progression. This review highlights specific compounds that not only exhibit significantly higher antiproliferative activities but also demonstrate lower toxicity compared to traditional chemotherapy agents.

Biological Evaluation of a Series of Amine-Containing Mixed-Ligand Copper(II) Coordination Compounds with 2-(2-hydroxybenzylidene)--(prop-2-en-1-yl)hydrazinecarbothioamide.

Five compounds 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide (H2L), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]hydrazinylidene}methyl)phenolato-S,N,O:O]diaquadicopper(II) nitrate (1), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]hydrazinylidene}methyl)phenolato-S,N,O:O]diimidazoldicopper(II) nitrate (2), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper(II) nitrate (3), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds toward cancer cell lines RD, HeLa, and normal cell line MDCK have been investigated. The tested complexes surpass Doxorubicin (DOXO) in the efficiency of anticancer activity as their IC50 values toward cancer cells are lower than the corresponding values of DOXO and the selectivity indexes exceed the corresponding SI value of DOXO.

Screening of biological properties of MoOS- and MoO-based coordination complexes: Investigation of antibacterial, antifungal, antioxidative and antitumoral activities versus growing of Spirulina platensis biomass.

This paper deals with the biological potential of coordination compounds based on binuclear core [MoOE] (E = O or S) coordinated with commercially available ligands such as oxalates (Ox), L-cysteine (L-cys), L-histidine (L-his), Iminodiacetate (IDA), Nitrilotriacetate (HNTA or NTA) or ethylenediamine tetraacetate (EDTA) by means of various in vitro assays in a screening approach. Results suggest that the obtained complexes show weak antibacterial and antifungal properties while not being cytotoxic on cancerous and mammalian cells. In contrast, [MoOE(L-cys)] complexes stand out as powerful antioxidant, whereas [MoOE(EDTA)] associating tetraphenylphosphonium counter-cations display strong antibiotic activity.

Abamectin Efficacy on the Potato Cyst Nematode .

The potato cyst nematode is a major pest of the potato crop. Abamectin is a biological pesticide showing high nematicide activity, but its efficacy to control has not been investigated to date. In this study, combination of different abamectin concentrations ranging from 1.

Age-dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages.

Progressive generation of total joint implant-derived wear particles is one of the major risk factors in development of peri-prosthetic osteolysis especially in the aging society. It is commonly accepted that macrophages predominantly drive the inflammatory response to wear debris particles. Among various surface receptors that activate the macrophages to phagocytize particles, it is believed that the Toll-like receptor 4 (TLR4) and the scavenger macrophage receptor with collagenous structure (MARCO) play key roles in recognition of wear debris particles.

Change of strategy or always overlooked? Third recent record of the beardless tadpole goby Benthophiloides brauneri from an inland location far from the coast.

The present study documents three specimens of Benthophiloides brauneri from the River Dniester. It is one of the rarest freshwater fishes in Europe, living along the western coast of the Black and Asov Seas, but these new records are 200 river km from the coast. We discuss whether the species has recently started to establish inland populations or inland specimens have previously been overlooked.

Circulation of Dirofilaria repens and Dirofilaria immitis in Moldova.

Background: Over the last two decades, a significant spread of dirofilariasis has been observed in eastern and central Europe. However, data on the circulation of Dirofilaria spp. in Moldova were absent although direct neighbor states reported high incidence rates of human dirofilariasis.

Comparison of tick-borne microorganism communities in Ixodes spp. of the Ixodes ricinus species complex at distinct geographical regions.

Characterizing the tick-borne microorganism communities of Ixodes ricinus (sheep tick) and Ixodes persulcatus (taiga tick) from the I. ricinus species complex in distinct geographical regions of Eastern Europe and European Russia, we demonstrated differences between the two ticks. Taiga ticks were more frequently mono- and co-infected than sheep ticks: 24.

Annotated checklist of the mosquitoes of the Republic of Moldova.

The mosquito fauna of the Republic of Moldova is poorly known. In an effort to understand the Culicidae fauna better, mosquito collections have been conducted between early April and middle November from 2008 to 2012. A total of 10,923 larval specimens and 8,246 adults were collected from 20 regions of Moldova.

Molecular detection of tick-borne pathogens in Ixodes ricinus from Moldova collected in 1960.

This study is the first report about the prevalence of tick-borne pathogens, as well as their (co-)infection rates, in the museum-archived I. ricinus female ticks collected in Moldova in 1960. A total of 16.

Detection of Babesia Sp. EU1 and members of spotted fever group rickettsiae in ticks collected from migratory birds at Curonian Spit, North-Western Russia.

To reveal the prevalence of spotted fever group (SFG) rickettsiae and Babesia sp. in Ixodes ricinus (L.) ticks from migratory birds, 236 specimens represented 8 species of Passeriformes and were collected at Curonian Spit in Kaliningrad enclave of North-Western Russia.

First report of Anaplasma phagocytophilum and its co-infections with Borrelia burgdorferi sensu lato in Ixodes ricinus ticks (Acari: Ixodidae) from Republic of Moldova.

We examined 198 questing Ixodes ricinus ticks collected in Chisinau City, Republic of Moldova by PCR assays for Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato and co-infection of both pathogens, which were detected in 9%, 25.2% and 2.5% of tested ticks, respectively.