A Qualitative Study Examining Caregivers' Perspectives on Healthcare System Barriers and Facilitators to Foregut Cancer Care.

Introduction: Caregivers play a critical role in supporting patients with foregut cancer by providing financial, psychosocial, and practical support to patients throughout their treatment journey. However, caregiver perspectives on challenges and supports to accessing cancer care remain understudied. This qualitative study aims to understand caregiver-reported barriers to and facilitators of foregut cancer care.

Attrition after Neoadjuvant Chemotherapy in Foregut Cancer: Experience at a Tertiary Center in the Deep South.

Background: Neoadjuvant chemotherapy (NAC) is increasingly used in the management of foregut cancers to downstage tumors, treat micrometastases, and improve oncological outcomes. However, many patients fail to undergo surgical resection after NAC. This study aims to identify the underlying causes of non-tumor biology-related attrition and thus evaluate the potentially modifiable factors contributing to pre-surgical attrition.

Unseen burden: Exploring caregiver experiences, barriers, and facilitators in foregut cancer care.

Introduction: Caregivers play a pivotal role in supporting foregut cancer patients, yet their experiences and the challenges they face are overlooked. Understanding caregivers' experiences and the barriers and facilitators they encounter can inform interventions to improve their well-being and, ultimately, patient outcomes. This study focuses on the lived experiences and the interpersonal factors that shape the caregivers' journeys.

Severe Aplastic Anemia Complicated with Fatal Invasive Fungal Infections in a Young Patient Harboring Perforin Gene Polymorphisms.

Background: Severe aplastic anemia (SAA) is an uncommon life-threatening disorder characterized by hypocellular bone marrow and pancytopenia. It is typically associated with immune-mediated mechanisms, requiring immunosuppressive therapy (IST) or hematopoietic stem cell transplantation (HSCT). Infections, especially invasive fungal infections such as mucormycosis and aspergillosis, constitute principal causes of morbidity and mortality in patients with SAA.

Disparities in access to surgical resection in patients with pancreatic cancer - a systematic review.

Background: Surgical resection is a crucial component of pancreatic cancer treatment. However, multiple disparities in access to surgical resection have been reported. This systematic review aimed to critically assess and summarize these disparities to improve equity in cancer care.

Patient-Reported Barriers to Foregut Cancer Care in the Deep South.

Background: Many patients with foregut cancer do not receive guideline-concordant treatment (GCT). Although social determinants of health (SDOH) have been associated with differences in receipt of GCT, the underlying mechanisms that perpetuate these disparities remain unknown. This mixed-methods study explored barriers to receipt of care among patients with foregut cancer.

An Overview for Clinicians on Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas.

Currently, there is no reliable method of discerning between low-risk and high-risk intraductal papillary mucinous neoplasms (IPMNs). Operative resection is utilized in an effort to resect those lesions with high-grade dysplasia (HGD) prior to the development of invasive disease. The current guidelines recommend resection for IPMN that involve the main pancreatic duct.

Approach to Acute Myeloid Leukemia with Increased Eosinophils and Basophils.

There is remarkable morphologic and genetic heterogeneity in acute myeloid leukemia (AML). In a small percentage of cases of AML, increased eosinophils and/or basophils are present in the bone marrow and sometimes in the peripheral blood. This is often a puzzling diagnostic situation but also an important finding that requires special investigation.

COVID-19 vs. Cancer Immunosurveillance: A Game of Thrones within an Inflamed Microenviroment.

The COVID-19 pandemic accounts for more than 500 million confirmed infections and over 6 million deaths worldwide in the last 2 years. SARS-CoV-2 causes a highly complex form of inflammation that affects the human organism both acutely and chronically. In the same line, cancer as an inflammation-induced and immune-editing disease appears to cross-react with immune system at different levels including early interactions during carcinogenesis and later cross-talks within the tumor microenvironment.

Causes of double-negative T-cell lymphocytosis in children and adults.

Aims: The causes and diagnosis of 'double-negative' (CD3+CD4-CD8-) T-cell lymphocytosis are not well studied. We aimed to define the causes of double-negative T-cell lymphocytosis in children and adults, and to identify simple clinical and laboratory features that would help to differentiate between the underlying conditions.

Methods: We collected clinical and laboratory data on 10 children and 30 adults with significantly increased peripheral-blood double-negative T-cells (>10% of total lymphocytes).

Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages.

During macrophage activation, expression of IL-1R-associated kinase (IRAK)-M is induced to suppress TLR-mediated responses and is a hallmark of endotoxin tolerance. Endotoxin tolerance requires tight regulation of genes occurring at the transcriptional and epigenetic levels. To identify novel regulators of IRAK-M, we used RAW 264.