ARSK-Related Mucopolysaccharidosis Type 10.

Mucopolysaccharidosis type 10 (MPS10) is a recently discovered lysosomal storage disorder caused by biallelic loss of function variants in ARSK. To date, 10 ARSK-related MPS10 patients from six families have been reported, with a median age at presentation of 9.5 years.

Thyroid Dysfunction and Kidney Dysfunction.

Objectives: The incidence and prevalence of chronic kidney disease (CKD) are rising worldwide. It is becoming more common in the developing world with the increasing impact of non-communicable diseases in these countries. Also, autoimmune disorders, including thyroid dysfunction are more common and may worsen the clinical status of patients with CKD.