Publications by authors named "Inhyeok Baek"
Article Synopsis
- Maladaptive feeding behaviors are identified as a leading cause of obesity in modern society, and while research on the lateral hypothalamic area (LHA) and its influence on eating exists for rodents, similar studies in primates were lacking.
- A study involving three macaques utilized chemogenetics to activate LHA GABAergic neurons, revealing that this activation increased goal-directed eating behaviors and heightened motivation for palatable food.
- The research confirmed the effects using imaging techniques, showing that LHA activation enhanced connectivity with frontal brain areas while reducing connectivity among those areas, suggesting potential implications for understanding obesity therapies in both primates and humans.
Purpose: Although eating is imperative for survival, few comprehensive methods have been developed to assess freely moving nonhuman primates' eating behavior. In the current study, we distinguished eating behavior into appetitive and consummatory phases and developed nine indices to study them using manual and deep learning-based (DeepLabCut) techniques.
Method: The indices were utilized to three rhesus macaques by different palatability and hunger levels to validate their utility.
For survival, it is crucial for eating behaviours to be sequenced through two distinct seeking and consummatory phases. Heterogeneous lateral hypothalamus (LH) neurons are known to regulate motivated behaviours, yet which subpopulation drives food seeking and consummatory behaviours have not been fully addressed. Here, in male mice, fibre photometry recordings demonstrated that LH leptin receptor (LepR) neurons are correlated explicitly in both voluntary seeking and consummatory behaviours.
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