Periosteal Fenestration Procedure in Apically Positioned Flap Increases the Attached Mucosal Width: An In Vivo Experimental Study.

Aim: To evaluate the efficacy of the apically positioned flap (APF) with periosteal fenestration in increasing the width of the masticatory mucosa (MM, including attached and keratinized mucosa) and to assess the histological properties of the MM gained through this technique.

Materials And Methods: Six mongrel dogs were treated using a split-mouth design, with APF alone (control) and APF with periosteal fenestration (test) applied from the first to the fourth maxillary premolars on both sides (total of 48 sites). Clinical MM width (cMW) and digitally scanned MM width (dMW) were measured at baseline, post-operatively, and after 8 weeks of healing.

Localized Sound-Integrated Display Speaker Using Crosstalk-Free Piezoelectric Vibration Array.

Beyond visual quality, features like sound and tactile feedback have become essential to enhancing user experience, resulting in more immersive, realistic displays. Multisensory displays engaging multiple senses are increasingly in demand. Panel-integrated piezoelectric speakers represent a major advancement in audio-visual technology, merging sound generation with display panels to enable compact, versatile designs in thin, flexible formats.

Integrating Cementum to the Dental Implant Abutment to Facilitate Connective Tissue Insertion: Histologic and FE-SEM Observations.

The peri-implant mucosal barrier 'seal' plays a significant role in maintaining peri-implant health, but its efficacy in the presence of inflammation is lower than that of natural teeth due, primarily, to the absence of collagen fiber insertion into the implant/abutment surface. To test the influence of cementum upon collagen fiber insertion/orientation after tooth removal, a customized root-cementum abutment was fabricated using a natural tooth root fragment. For that, an extracted root fragment, preserving both cementum and periodontal ligament, was cemented to the titanium abutment and used as a healing abutment of an immediate implant placed into the fresh extraction socket.

CYP4X1 Expression Is Associated with Metastasis and Poor Prognosis in Patients with Colorectal Cancer.

Globally, the mortality rate of colorectal cancer (CRC) remains high. Despite the development of various treatments, such as targeted therapy and immunotherapy, colorectal cancer continues to be a serious health issue worldwide. Identifying new biomarkers is essential for improving prognosis and tailoring targeted therapies for CRC.

TM7SF2 as a Potential Biomarker in Colorectal Cancer: Implications for Metastasis.

Colorectal cancer (CRC) is a commonly fatal cancer and ranks as the fourth most prevalent in men and third in women worldwide. While early-stage survival rates are high, they significantly decrease with recurrence and metastasis. Thus, the early detection and treatment of metastasis-related factors can significantly improve survival rates.

Local delivery of pamidronate with collagen matrix mitigates buccal bone resorption following immediate implant placement - An experimental in vivo study.

Aims: The aim of this experimental in vivo pilot study was to evaluate the effect of the local delivery of pamidronate within a collagen membrane on the changes in the buccal soft and hard tissue dimensions at the time of immediate implant placement and whether this effect was influenced by the placement of bone substitutes.

Methods: In six beagle dogs, the distal roots of the third and fourth premolars were extracted, and immediate implants were placed. Treatment groups were randomly allocated to each socket: (i) covering the buccal bone with pamidronate-soaked collagen membrane (BP group), (ii) filling the gap defect with synthetic bone substitute (BS group), (iii) filling the gap defect with synthetic bone substitute and covering the buccal bone with pamidronate soaked collagen membrane (BP/BS group), (iv) no treatment (control group).

SNPs in microRNA seed region and impact of miR-375 in concurrent regulation of multiple lipid accumulation-related genes.

Bovine intramuscular fat (IMF), commonly referred to as marbling, is regulated by lipid metabolism, which includes adipogenesis, lipogenesis, glycerolipid synthesis, and lipolysis. In recent years, breeding researchers have identified single nucleotide polymorphisms (SNPs) as useful marker-assisted selection tools for improving marbling scores in national breeding programs. These included causal SNPs that induce phenotypic variation.

Comprehensive treatment protocol for peri-implantitis: an up-to date narrative review of the literature.

This narrative review describes up-to-date treatment options for peri-implantitis and proposes a treatment protocol and flowchart based on the current scientific evidence. Peri-implantitis treatment should be based on the phased treatment protocol for periodontitis, which is a continuous flow of decisions for extraction, nonsurgical and surgical treatments with step-by-step re-evaluation. The protocol's goals are to fulfill the success criteria for peri-implantitis treatment (probing depth of ≤5 mm, and absence of bleeding on probing, suppuration, and progressive bone loss) and to halt disease progression.

The Relationship between Social Network Service Use Motives and Subjective Well-Being: The Mediating Effect of Online and Offline Social Capital.

Objective: The purpose of this study was to examine the mediating effect of social capital on the relationship between Social Media use motives and subjective well-being.

Methods: In the study, online self-reporting surveys were conducted with Social Media users in their 20s, and data from 445 participants were used for structural equation modeling.

Results: The main findings of the study were as follows.

High Expression of Tetraspanin 5 as a Prognostic Marker of Colorectal Cancer.

Cancer is a major disease and the leading cause of death worldwide, with colorectal cancer (CRC) being the third-most common cancer in Korea. The survival rate associated with CRC reduces as the disease stage increases. Therefore, its early detection and treatment can greatly increase patient survival rates.

High expression of LY6E is an independent prognostic factor of colorectal cancer patients.

Colorectal cancer (CRC) is common cancer worldwide, and the 5‑year relative survival rate of CRC patients with distant metastasis is as low as 14%. Therefore, identifying markers of CRC is important for the early detection of CRC and applying appropriate treatment strategies. The lymphocyte antigen 6 family (LY6 family) is closely related to the behavior of various cancer types.

Expression of Spermine Oxidase Is Associated with Colorectal Carcinogenesis and Prognosis of Patients.

Uncovering tumor markers of colorectal cancer is important for the early detection and prognosis of the patients. Spermine oxidase (SMOX) is upregulated in various cancers. The present study aims to explore the biologic function and expression patterns of SMOX in colorectal cancer (CRC), the third most common type of cancer worldwide.

Anti-Inflammatory Potential of Complex Extracts of Matsum. & Koidz. and L. Sprout in Chronic Gingivitis: In Vitro Investigation and Randomized Clinical Trial.

Complex extracts of Matsum. & Koidz. (LSE) and L.

3D-Printed Barrier Membrane Using Mixture of Polycaprolactone and Beta-Tricalcium Phosphate for Regeneration of Rabbit Calvarial Defects.

Background: Polycarprolactone and beta tricalcium phosphate (PCL/β-TCP) are resorbable biomaterials that exhibit ideal mechanical properties as well as high affinity for osteogenic cells.

Aim: Objective of this study was to evaluate healing and tissue reaction to the PCL/β-TCP barrier membrane in the rabbit calvaria model for guided bone regeneration.

Materials And Methods: The PCL/β-TCP membranes were 3D printed.

Diverse patterns of bone regeneration in rabbit calvarial defects depending on the type of collagen membrane.

Purpose: Various crosslinking methods have been introduced to increase the longevity of collagen membranes. The aim of this study was to compare and evaluate the degradation and bone regeneration patterns of 3 collagen membranes.

Methods: Four 8-mm-diameter circular bone defects were created in the calvaria of 10 rabbits.

Clinical and Microbiological Efficacy of Pyrophosphate Containing Toothpaste: A Double-Blinded Placebo-Controlled Randomized Clinical Trial.

(1) Background: Dental calculus works as a niche wherein pathogenic bacteria proliferate in the oral cavity. Previous studies revealed the anticalculus activity of pyrophosphates, however there was no clinical study that evaluated microbiome changes associated with calculus inhibition. Therefore, the aim of this randomized clinical trial was to evaluate the calculus inhibition of pyrophosphate-containing toothpaste and its effect on oral microbiome changes.

Oral Fluid Biomarkers for Diagnosing Gingivitis in Human: A Cross-Sectional Study.

Diagnoses based on oral fluid biomarkers have been introduced to overcome limitations of periodontal probe-based diagnoses. Diagnostic ability of certain biomarkers for periodontitis have been identified and widely studied, however, such studies targeting gingivitis is scarce. The aims of this study were to determine and compare the efficacies and accuracies of eight biomarkers in diagnosing gingivitis with the aid of receiver operating characteristic (ROC) curves.

Distinctive bone regeneration of calvarial defects using biphasic calcium phosphate supplemented ultraviolet-crosslinked collagen membrane.

Purpose: To overcome several drawbacks of chemically-crosslinked collagen membranes, modification processes such as ultraviolet (UV) crosslinking and the addition of biphasic calcium phosphate (BCP) to collagen membranes have been introduced. This study evaluated the efficacy and biocompatibility of BCP-supplemented UV-crosslinked collagen membrane for guided bone regeneration (GBR) in a rabbit calvarial model.

Methods: Four circular bone defects (diameter, 8 mm) were created in the calvarium of 10 rabbits.

Isolation of Abscisic Acid from Korean Acacia Honey with Anti- Activity.

Background: () is linked to the development of the majority of peptic ulcers and some types of gastric cancers, and its antibiotic resistance is currently found worldwide.

Objective: This study is aimed at evaluating the anti- activity of Korean acacia honey and isolating the related active components using organic solvents.

Material And Methods: The crude acacia honey was extracted with -hexane, dichloromethane, ethyl acetate (EtOAc), and -butanol.

Pyrosequencing analysis of the bacterial communities in the guts of honey bees Apis cerana and Apis mellifera in Korea.

The bacterial communities in the guts of the adults and larvae of the Asian honey bee Apis cerana and the European honey bee Apis mellifera were surveyed by pyrosequencing the 16S rRNA genes. Most of the gut bacterial 16S rRNA gene sequences were highly similar to the known honey bee-specific ones and affiliated with Pasteurellaceae or lactic acid bacteria (LAB). The numbers of operational taxonomic units (OTUs, defined at 97% similarity) were lower in the larval guts (6 or 9) than in the adult guts (18 or 20), and the frequencies of Pasteurellaceae-related OTUs were higher in the larval guts while those of LAB-related OTUs in the adult guts.

Prevalence of Nosema and Virus in Honey Bee (Apis mellifera L.) Colonies on Flowering Period of Acacia in Korea.

Honey production from approximately 1.6 million colonies owned by about 199,000 Korean beekeepers was almost 23,000 metric tons in 2009. Nosema causes significant losses in honey production and the virus decreases population size.

Synnemata Production Using Silkworm Variety, Female Yangwonjam by Isaria tenuipes.

This study was conducted to confirm the possible use of female Yangwonjam as a host for synnemata production of Isaria tenuipes in eight local areas in Korea. Silkworm pupation rate, infection rate and synnemata characteristics of I. tenuipes were examined.

Insight into the 6-thiopurine-mediated termination of the invasive motility of tumor cells derived from inflammatory breast cancer.

Our study showed that a combination of 6-thiopurine (6-TP) drugs and a redox agent effectively inhibits the motility of SUM cells derived from human inflammatory breast cancer (IBC) cells and RhoC-overexpressed mammary epithelium cells. This 6-TP-mediated inhibition of cell motility occurs because the treated 6-TPs target and inactivate RhoC. A molecular mechanism for inactivation by the 6-TP-mediated RhoC is proposed by which treated TPs are converted in cells into 6-thioguanosine phosphate (6-TGNP).