Publications by authors named "Ilya A Pletenev"
Dictyostelium discoideum is a unicellular slime mold, developing into a multicellular fruiting body upon starvation. Development is accompanied by large-scale shifts in gene expression program, but underlying features of chromatin spatial organization remain unknown. Here, we report that the Dictyostelium 3D genome is organized into positionally conserved, largely consecutive, non-hierarchical and weakly insulated loops at the onset of multicellular development.
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- Chromatin structure plays a crucial role in determining gene expression and cell identity, especially in neurons, through the action of polycomb group (PcG) proteins.
- A study mapping the 3D genome in neuronal and non-neuronal cells from the Wernicke's area shows that neurons have less separation between active and inactive gene regions compared to other brain cells.
- Neuronal cells display unique chromatin interactions, including a specific network of PcG contacts linked to genes that control development, with a distinct pattern of histone modifications that suggest a functional significance of these interactions for neuron identity.