DNA-Binding Properties of Non-Intercalating Water-Soluble Organometallic Ir(III) Luminophores.

A series of Ir(III) complexes, [Ir(C^N)(en)] (where C^N = 2-phenyl-benzo[d]thiazolyl cyclometalating ligand; en = ethylene diamine), is reported with structural variation via a substituent (H, Me, OMe, Cl, OCF) at the coordinated phenyl ring. The complexes were soluble in aqueous buffer, with solubility limits correlating inversely with the predicted logP. The complexes display efficient visible absorption at 400-500 nm (ε ∼ 5000 M cm) due to charge-transfer transitions and are triplet emitters in aerated buffer (λ = 529-540 nm; lifetimes up to 0.

Tuning Excited State Character in Iridium(III) Photosensitizers and Its Influence on TTA-UC.

A series of mixed ligand, photoluminescent organometallic Ir(III) complexes have been synthesized to incorporate substituted 2-phenyl-1-naphtho[2,3-]imidazole cyclometalating ligands. The structures of three example complexes were categorically confirmed using X-ray crystallography each sharing very similar structural traits including evidence of interligand hydrogen bond contacts that account for the shielding effects observed in the H NMR spectra. The structural iterations of the cyclometalated ligand provide tuning of the principal electronic transitions that determine the visible absorption and emission properties of the complexes: emission can be tuned in the visible region between 550 and 610 nm and with triplet lifetimes up to 10 μs.

Synthesis of 3,5-Bis(trifluoromethyl)phenyl-Substituted Pyrazole Derivatives as Potent Growth Inhibitors of Drug-Resistant Bacteria.

Enterococci and methicillin-resistant (MRSA) are among the menacing bacterial pathogens. Novel antibiotics are urgently needed to tackle these antibiotic-resistant bacterial infections. This article reports the design, synthesis, and antimicrobial studies of 30 novel pyrazole derivatives.

Synthesis of Chimeric Thiazolo-Nootkatone Derivatives as Potent Antimicrobial Agents.

Nootkatone, an approved insecticide, is a well-known natural product from grapefruit. A series of fused-thiazole derivatives of nootkatone have been synthesized, and these new compounds were tested against several strains of bacteria. Some of these compounds are found to be potent antimicrobial agents against Staphylococcus aureus and Enterococcus faecium with minimum inhibitory concentration (MIC) values as low as 1.

Benign Synthesis of Fused-thiazoles with Enone-based Natural Products and Drugs for Lead Discovery.

In an effort to synthesize a library of bioactive molecules, we present an efficient synthesis of fused-thiazole derivatives of natural products and approved drugs by using an environmentally usable solvent, acetic acid, and without any external reagent. Cholestenone, ethisterone, progesterone, and nootkatone-derived epoxyketones have been utilized to synthesize 50 novel compounds. The plausible mechanism of the reaction has been determined by theoretical calculation using M06-2X/6-31+G(d,p).