Publications by authors named "Hyeon Jae Kwon"
Decellularized extracellular matrix (dECM) exhibits tissue-specific pro- or anti-angiogenic effects. Previous studies have demonstrated that matrix-bound nanovesicles (MBVs) act as key bioactive components of dECM, replicating various biological functions such as anti-inflammatory and immunomodulatory effects. Building on this evidence, this study hypothesized that MBVs derived from cartilage and small intestinal submucosa (SIS) modulate angiogenesis through the selective packaging of miRNAs.
View Article and Find Full Text PDFImmunomodulation Effects of Porcine Cartilage Acellularized Matrix (pCAM) for Osteoarthritis Treatment.
Tissue Eng Regen Med
June 2025
Background: Pain reduction, immunomodulation, and cartilage repair are key therapeutic goals in osteoarthritis (OA) treatment. In this study, we evaluated the therapeutic effects of porcine cartilage acellularized matrix (pCAM) derived from naive tissue and compared it with the synthetic material polynucleotides (PN) for OA treatment.
Methods: pCAM was produced from porcine cartilage through physicochemical processing.
Article Synopsis
- Degenerative meniscus tears (DMTs) commonly occur in osteoarthritic knees, with current treatment focused on surgical removal rather than regeneration, which may worsen arthritis.
- Research into regenerating meniscus tissue is complicated by its complex structure and the need for growth factors, but a new approach proposes using decellularized meniscus extracellular matrix (DMECM) combined with patient-derived stem cells without these additional components.
- This method successfully creates meniscus tissue that mimics natural characteristics and structure, showing promising results in a pig model, indicating the potential for improved treatment options for patients with DMTs.
Osteochondral allograft (OCA) is an important surgical procedure used to repair extensive articular cartilage damage. It is known that chondrocyte viability is crucial for maintaining the biochemical and biomechanical properties of OCA, which is directly related to the clinical success of the operation and is the only standard for preoperative evaluation of OCA. However, there is a lack of systematic research on the effect of the content of cellular matrix in OCA cartilage tissue on the efficacy of transplantation.
View Article and Find Full Text PDFBackground: We recently analyzed the joint capsule adjacent to the medial meniscus and found that the perimeniscal joint capsule has collagen fiber orientation similar to that of circumferential meniscal fibers, potentially playing a role in preventing extrusion.
Purpose: To analyze the meniscal extrusion prevention potential of the circumferential rim augmentation suture around the perimeniscal capsule in a rabbit root tear model and analyze the biomechanical function in a porcine cadaveric knee.
Study Design: Controlled laboratory study.
Article Synopsis
- The meniscus is composed of three microstructural zones: inner fibrocartilage, middle transitional, and outer fibrous zone, each with unique properties.
- Researchers hypothesized that decellularized meniscus extracellular matrix (DMECM) varied based on its zone of origin and explored its biochemical characteristics and interactions with cells for tissue engineering.
- Findings revealed that the inner DMECM had the highest glycosaminoglycan content and better cell interaction, while middle DMECM was higher in collagen; outer DMECM exhibited more fibrous traits, suggesting potential for targeted tissue engineering applications.