Publications by authors named "Hyebin Cha"
Breast cancer is a major global health burden with high morbidity and mortality rates. Previous studies have reported that increased expression of ASAP1 is associated with poor prognosis in various types of cancer. This study was conducted on 452 breast cancer patients who underwent surgery at Hanyang University Hospital, Seoul, South Korea.
View Article and Find Full Text PDFEffects of Cortactin Expression on Prognosis in Patients with Breast Cancer.
Diagnostics (Basel)
September 2023
Background: Cortactin is overexpressed in several types of invasive cancers. However, the role of cortactin expression in breast cancer prognosis has not been sufficiently elucidated. Therefore, we investigated the clinicopathological significance of cortactin in breast cancer.
View Article and Find Full Text PDFSingle-stranded DNA binding protein 2 (SSBP2) is a tumor suppressor candidate. In this study, the expression level and clinicopathological significance of SSBP2 in squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) were evaluated. We also identified biological pathways associated with a set of genes potentially related to SSBP2.
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- CADM4 is identified as a tumor-suppressor candidate that is involved in cell interactions, and its role in gallbladder cancer (GBC) was evaluated in this study.
- Low levels of CADM4 expression were linked to more advanced stages of cancer and worse prognosis, indicating its potential significance in the aggressiveness of GBC.
- The findings suggest that CADM4 expression may serve as an important prognostic marker for patient outcomes in gallbladder cancer.
Low MTUS1 Protein Expression Is Associated with Poor Survival in Patients with Colorectal Adenocarcinoma.
Diagnostics (Basel)
March 2023
Introduction: Microtubule-associated tumor suppressor 1 (MTUS1) is a novel tumor suppressor protein involved in cell proliferation, migration, and tumor growth. MTUS1 is thought to be downregulated in various human cancers and associated with poor prognosis. We evaluated the clinicopathologic significance and prognostic value of MTUS1 in colorectal adenocarcinoma.
View Article and Find Full Text PDFCD47 Expression Predicts Unfavorable Prognosis in Clear Cell Renal Cell Carcinoma after Curative Resection.
Diagnostics (Basel)
September 2022
Article Synopsis
- CD47 acts as a 'do not eat me' signal that prevents macrophages from engulfing tumor cells, making it a target for immune checkpoint therapy currently being studied in various cancers.
- In a study of 235 clear cell renal cell carcinoma (ccRCC) tissues, CD47 expression was found in 11.9% of cases and correlated with more aggressive tumor features, including higher grades and stages.
- Positive CD47 expression was linked to poorer cancer-specific survival, although it did not impact recurrence-free survival rates.
Clinicopathological Implications of ASAP1 Expression in Hepatocellular Carcinoma.
Pathol Oncol Res
September 2022
Article Synopsis
- ASAP1, a protein linked to cancer, is found to be expressed more in various cancers, particularly in hepatocellular carcinoma (HCC), suggesting its potential as a prognostic marker.
- In a study of 149 HCC tissue samples, high expression of ASAP1 was linked to male gender, advanced tumor grade, vessel invasion, and higher cancer stages.
- Increased ASAP1 expression correlated with poorer overall survival and recurrence-free survival in HCC patients, indicating it could serve as a significant prognostic biomarker for this type of cancer.
CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications.
Diagnostics (Basel)
July 2022
CD47 is a cell surface molecule and regulates diverse cellular responses. CD47 is highly expressed in cancer cells and has potential as a therapeutic target and prognostic factor in cancer patients. The expression patterns of CD47 in basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and its precursor lesions, and its clinicopathological significance were investigated.
View Article and Find Full Text PDFDecreased Expression of Cell Adhesion Molecule 4 in Gastric Adenocarcinoma and Its Prognostic Implications.
Diagnostics (Basel)
April 2022
Cell adhesion molecule 4 (CADM4) is a novel tumor suppressor candidate. The prognostic implications of CADM4 in gastric cancer have not been conclusively elucidated. Therefore, we evaluated the clinicopathological significance and prognostic value of CADM4 expression in a large series of patients with gastric adenocarcinoma.
View Article and Find Full Text PDFBackground: Single-stranded DNA binding protein 2 () is involved in the DNA damage response and the maintenance of genome stability. Previous studies have suggested that has a tumor suppressor function or oncogenic function. Loss of expression has been reported in various tumors.
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