Effects of different concentrations of a white grape marc extract on broiler performance, apparent ileal digestibility, antioxidant capacity, intestinal barrier function and nutrient transport markers.

The current study evaluated the effect of a white grape marc extract (GME) on growth performance, gut health, and intestinal function in broiler chickens at different dosages to determine a dose-related efficacy of the extract without inducing any adverse effects. Four hundred male broiler chickens received a basal diet without (CON) or with the GME at different levels, based on its polyphenolic concentration: 200 (LPP), 750 (MPP), and 1,500 (HPP) mg/kg, respectively. Growth performance parameters were recorded during the whole trial.

Nuciferine improves high-fat diet-induced obesity reducing intestinal permeability by increasing autophagy and remodeling the gut microbiota.

Nuciferine (NF) has received extensive attention due to its medicinal value in the treatment of metabolic diseases, such as obesity; however, to date, the effects of NF on obesity-related intestinal permeability, autophagy and the gut microbiota have not been investigated. Herein, C57BL/6J mice were fed either a chow or a high-fat diet (HFD) with or without NF for 8 weeks. The results showed that NF supplement reduced weight gain, fat accumulation and intestinal permeability in the HFD mice accompanied by improved autophagy.