Publications by authors named "Hui-Ru Cheng"
Article Synopsis
- Stress negatively impacts ovarian function, leading to issues like premature ovarian insufficiency (POI), as shown in experiments with chronic unpredictable mild stress (CUMS) in mice.
- CUMS caused changes in important ovarian and mitochondrial proteins, indicating mitochondrial dysfunction and increased cell death and self-digestion (autophagy) in the ovaries.
- Melatonin (MT) showed potential to reverse these negative effects on ovarian health by inhibiting a specific pathway (eIF2α-AFT4), suggesting it could be a treatment for stress-induced reproductive issues.
Background: Previous studies have shown that serotonin and its receptors are widely distributed in mammalian reproductive tisssues and play an important role in embryonic development. However, the specific effects of the serotonergic system on embryonic arrest (EA) and the underlying mechanism require further investigation.
Methods: Chorionic villi were collected from patients with EA and healthy pregnant women.