Dual-mode delivery of canine parvovirus type 2c VP2 protein in recombinant Lactobacillus plantarum: Surface display and intracellular expression systems.

Canine parvovirus type 2 (CPV-2) causes an acute and highly transmissible disease characterized by severe hemorrhagic enteritis and myocarditis, ultimately resulting in the death of dogs and wild carnivores. At present, although vaccines have been developed for CPV-2, there are no specific and effective vaccines available for prevention of CPV-2c infection. To develop mucosal vaccines against CPV-2c, we constructed recombinant Lactobacillus plantarum (L.