Publications by authors named "HuaFang Guan"
Smoking is considered the most common addictive behavior worldwid. However, it is not systematically investigated whether there are bidirectional causal associations between tobacco use and neuroimaging, which might provide potential neural biomarkers or therapeutic neuro-targets for tobacco abuse or rehabilitation. In this study, using Mendelian randomization (MR), we explored both forward and reverse causal relationships between 4 tobacco use phenotypes (including Cigarettes per day, Smoking initiation, Age of initiation and Smoking cessation) and 209 neuroimaging features involving brain function and structure.
View Article and Find Full Text PDFPre-treatment of hyponatremia as a biomarker for poor immune prognosis in advanced or metastatic gastric cancer: A retrospective case analysis.
Hum Vaccin Immunother
December 2024
Article Synopsis
- * A study involving 268 AGC patients showed that those with hyponatremia had shorter progression-free survival (PFS) and overall survival (OS) compared to those with normal sodium levels.
- * Serum sodium levels emerged as a potential independent prognostic factor for both PFS and OS, suggesting that monitoring sodium may help predict patient outcomes, though more extensive studies are needed to confirm these findings.
Background: The emergence of immune checkpoint inhibitors (ICIs) has enhanced survival outcomes for certain patients with advanced biliary tract carcinoma (BTC). Pinpointing those who would benefit most from immunotherapy remains elusive. We investigated the predictive value of the modified Gustave Roussy Immune Score (mGRIm-s) in BTC patients treated with ICIs.
View Article and Find Full Text PDF