Publications by authors named "Hsin-Yin Hsu"

Background: Sarcopenia and osteoporosis increase the likelihood of disability and caregiving burden. While progressive resistance training (PRT) is effective in mitigating these outcomes, patients often struggle to find suitable, long-term training facilities, making it difficult to adhere to exercise prescriptions.

Objectives: This feasibility study aimed to familiarize patients with PRT through educational training by a geriatrician, enabling them to identify a suitable long-term community-based training program.

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Background: The relationship between different weight class and mortality risk remained uncertain in cervical cancer patients. Thus, we conducted the study to assess the association between different body weight classes and survival outcomes in patients with cervical cancer.

Methods: This was a retrospective cohort study including 6908 cervical cancer patients from the Taiwan Cancer Registry database.

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  • A study explored whole-exome sequencing (WES) to better understand severe hypertriglyceridemia by identifying genes linked to high triglyceride levels through a genome-wide association study (GWAS).
  • The GWAS involved over 120,000 participants and found that the APOA5 locus on chromosome 11 has the strongest association with triglyceride levels, alongside other significant genes like BUD13, GCKR, and LPL.
  • WES conducted on 29 patients with extreme hypertriglyceridemia identified additional genes such as ALDH1A2 and APOC1, highlighting both known and novel genetic factors that may influence lipid metabolism and open up possibilities for new treatments.
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  • The study investigates the link between serum 25-hydroxyvitamin D (25(OH)D) levels and stroke risk, observing that higher concentrations of this vitamin are associated with a lower likelihood of having a stroke.
  • Conducted from 1990 to 2011 with 1,778 participants, the research utilized observational and Mendelian randomization methods to analyze the data and found a significant correlation between increased 25(OH)D levels and decreased stroke risk, with a particular emphasis on hypertension as a mediating factor.
  • The findings suggest that maintaining adequate 25(OH)D levels may reduce stroke risk, and that managing blood pressure could be key in preventing strokes among those low in this vitamin.
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Context: The association between colorectal cancer (CRC) and new-onset diabetes mellitus remains unclear.

Objective: To examine the association between CRC and the risk of subsequent diabetes mellitus and to further investigate the impact of chemotherapy on diabetes mellitus risk in CRC.

Methods: In this nationwide cohort study using the Taiwan Cancer Registry database (2007-2018) linked with health databases, 86 268 patients with CRC and an equal propensity score-matched cohort from the general population were enrolled.

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  • Taller adults tend to have a lower risk of stroke compared to shorter individuals, with the study showing significant differences in risk based on height categories.
  • Systolic blood pressure plays a crucial role in this relationship, acting as a protective factor that helps mediate the association between height and stroke risk.
  • The findings suggest that managing systolic blood pressure could be an effective strategy for preventing strokes, particularly for those at risk.
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  • * Researchers followed breast cancer patients diagnosed between 2007 and 2016 in Taiwan and compared their health outcomes to a general population over time.
  • * Findings revealed a higher CAD risk shortly after diagnosis but no link between radiotherapy and increased CAD or stroke risk.
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Background: Although diabetes is a poor prognostic factor for colorectal cancer (CRC), whether diabetes severity provides an additional predictive value for CRC prognosis remains unclear. The study aimed to investigate the prognostic differences after curative CRC resection among patients with different diabetic severities.

Methods: This population-based retrospective cohort study analyzed data registered between 2007 and 2015 in the Cancer Registry Database, which is linked to the National Health Insurance Research Database and National Death Registry.

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Background: Evidence regarding postoperative CEA for predicting long-term outcomes of colorectal cancer remains controversial, especially in patients with normal postoperative CEA.

Objective: To investigate the risk difference among different postoperative CEA trajectories in patients with normal postoperative CEA after curative colorectal cancer resection.

Design: This cohort study was conducted at a comprehensive cancer center and included data retrieved from a prospectively collected database between January 2006 and December 2018.

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Background: Studies on disease burden in Taiwan are lacking. We aimed to quantify the burden of cardiovascular disease (CVD) attributable to high body mass index (BMI) in Taiwan.

Methods: Using a comparative risk assessment approach from the Global Burden of Disease study, we estimated the population attributable fraction (PAF), attributable CVD burden, and disability-adjusted life years (DALYs) according to sex, age, and area of residence in Taiwan.

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Background: This study aimed to determine whether primary parathyroid cancer patients were associated with increased metabolic and cardiovascular comorbidities in comparison to the general population.

Methods: We used the National Taiwan Cancer Registry Database to construct a cohort of patients with parathyroid cancer from January 1, 2004, to December 31, 2019. We compared the incidence of hypertension, diabetes mellitus, hyperlipidemia, atrial fibrillation, coronary heart disease, and heart failure with the general population matched based on a propensity score in a one-to-five fashion.

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Osteoporosis is a progressive metabolic bone disorder characterised by a decline in bone mineral density (BMD). Some previous studies have reported a controversial relationship between uric acid and osteoporosis. This cross-sectional study aimed to assess the association between serum uric acid levels and BMD in older adults from Taiwan.

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Background: The associations with cancer and cardiovascular diseases (CVD) had inconsistent results. The study aimed to investigate the risk of cardiovascular diseases (CVD) between populations with and without cancer.

Methods: Patients with common cancers in Taiwan were enrolled in the study between 2007 and 2018 using the Taiwan Cancer Registry.

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Treatment with levothyroxine and radioiodine contribute alternative cardiovascular function in adults with thyroid cancer. The risks of long-term cardiovascular conditions among thyroid cancer patients is unknown. This study aimed to compare the incidence of coronary heart disease (CHD), ischemic stroke (IS), and atrial fibrillation (AF) among adults with thyroid cancer with that of the general population, especially when stratified by age (< 65 and ≥ 65 years old).

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  • PCSK9 inhibitors are effective at lowering LDL cholesterol (LDL-C) and other atherogenic apolipoproteins in patients with hypercholesterolemia when used alongside statin therapy.
  • A systematic review analyzed 22 studies involving 42,786 patients, finding significant reductions in LDL-C (50-63%), apolipoprotein B (ApoB) (43-52%), and lipoprotein (a) [Lp(a)] (23-31%) with PCSK9 inhibitors compared to a placebo.
  • Evolocumab 140 mg every two weeks was particularly effective, showing the largest reductions in LDL-C, ApoB, and Lp(a), and no significant difference in adverse events compared
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Purpose: Evidence regarding the relationship between colorectal cancer and the risk of cardiovascular disease (CVD) is limited. Thus, in this study, we aimed to determine the standardised incidence ratio (SIR) of CVDs in colorectal cancer patients in Taiwan.

Methods: A population-based cohort study enrolling the incident colorectal cancer population based on the Cancer Registry Database from 2007 to 2016 was conducted (n = 94,233, mean age: 62.

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Background: To investigate the standardized incidence ratios (SIR) of stroke in patients with head and neck cancer and their relationship to radiotherapy.

Methods: Patients with head and neck cancer ages 20-85 years were enrolled from 2007 to 2016 using the Taiwan Cancer Registry. The study endpoint was fatal and non-fatal ischemic stroke, ascertained by the National Health Insurance Research Database.

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Objective: Many cancers are caused by overweight; however, cancer risk varies among individuals with obesity. Few studies are addressing the relationship between metabolic obesity phenotypes and cancer. This study investigates the association between metabolically healthy overweight (MHOW) or metabolically healthy obesity (MHO) and cancer incidence.

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The protective effect of different healthy lifestyle scores for the risk of cardiovascular disease (CVD) was reported, although the comparisons of performance were lacking. We compared the performance measures of CVDs from different healthy lifestyle scores among Taiwanese adults. We conducted a nationwide prospective cohort study of 6042 participants (median age 43 years, 50.

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Background: This study assessed the associations of metabolic obesity phenotypes with the risk of atrial fibrillation (Afib).

Methods: This prospective cohort study categorized Taiwanese adults according to their body mass index (BMI) and metabolic health status at baseline. We assigned the participants to the underweight (BMI < 18.

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  • Blood lipids play a crucial role in cellular growth, and their changing levels may have a significant impact on cancer risk, leading to mixed findings in previous studies.
  • A study conducted with 4,130 Taiwanese adults evaluated the relationship between blood lipid changes and the risk of developing cancer over a median follow-up of 13.4 years.
  • Results indicated that decreases in certain lipid levels (like total cholesterol, LDL-C, and non-HDL-C) were associated with a higher incidence of cancer, suggesting that unexpected declines in serum lipids could signal increased cancer risk.
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Although previous studies have investigated the relationship between fracture risk and type 2 diabetes (T2D), cohort studies that estimate composite osteoporosis risk are lacking. This retrospective cohort study sought to determine the risk of osteoporosis in Taiwanese patients with T2D. Patients diagnosed with T2D between 2002 and 2015 identified through the 2002 Taiwan Survey of Hypertension, Hyperglycemia, and Hyperlipidemia were included.

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Purpose: To examine the association between different phenotypes of obesity or metabolic syndromes and liver fibrosis score in a Taiwanese elderly population with fatty liver.

Patients And Methods: This cross-sectional study included 1817 participants aged ≥65 years with fatty liver diagnosed by sonography. We used ethnicity-specific criteria for body mass index and metabolic syndrome, and to define obesity phenotypes as metabolically healthy non-obese (MHNO), metabolically unhealthy non-obese (MUNO), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO).

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High baseline atherogenic lipid level has been an established risk factor for the risk of cardiovascular events. Evidence concerning the role of lipid changes in cardiovascular and death risks are inconclusive. A cohort study was conducted based on the Taiwanese Survey on Hypertension, Hyperglycemia, and Hyperlipidemia (n = 4072, mean 44.

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Objectives: To investigate the relationship between metabolically healthy obesity and cardiovascular disease risk in Taiwanese individuals.

Methods: Taiwanese individuals were recruited from a nationwide, representative community-based prospective cohort study and classified according to body mass index as follows: normal weight (18.5-23.

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