Expression of FFAR2 and FFAR3 in peripheral blood leukocytes: Correlation with coronary artery stenosis, calcium score, and serum IL-1β levels in male patients.

Background And Aims: Cardiovascular diseases pose a major health threat, with atherosclerosis being the leading cause. Free fatty acids (FFAs) can act as signaling molecules, influencing inflammation and oxidative stress, thereby potentially impacting atherosclerosis risk. This study examined the expression of FFAR2 and FFAR3 and their relationship with serum IL-1β, total antioxidant capacity (TAC), and malondialdehyde (MDA) levels in patients undergoing CT angiography.

Combined effects of IRAK inhibition and pioglitazone on hepatic inflammation and apoptosis in a mouse model of MASLD.

Background: Inflammation and apoptosis play crucial role in the progression of liver diseases. This study aimed to evaluate the effects of Interleukin-1 receptor-associated kinase inhibitor (IRAKi) in combination with pioglitazone on the expression of inflammatory and apoptotic markers in the liver of C57BL/6J mice subjected to a high-fat diet (HFD).

Methods: Male C57BL/6J mice were divided into five groups: Control (normal diet, ND), HFD, HFD-IRAKi, HFD-pioglitazone (HFD-PIO), and HFD-IRAKi-PIO.

Effect of environmental distraction on safety behavior: A path analysis approach.

BackgroundEnvironmental variables can affect employee safety in different ways. These variables can reduce attention and concentration and cause distraction. Numerous studies have been conducted to examine the impact of distraction on safety, with results that have been inconsistent.

Effectiveness of nutrition counseling in managing gestational weight gain and infant outcomes: a retrospective cohort study.

Background: Gestational weight gain (GWG) plays a crucial role in maternal and fetal health outcomes during pregnancy. Excessive weight gain is associated with various complications, emphasizing the importance of effective management strategies. Nutrition counseling has been proposed as a promising intervention to optimize GWG and improve maternal and infant outcomes.

Exploring serum miR-33b as a novel diagnostic marker for hypercholesterolemia and obesity: insights from a pilot case-control study.

Obesity and atherosclerosis are significant metabolic diseases characterized by disrupted lipid metabolism. MicroRNAs (miRNAs) are small, conserved, non-coding RNA sequences consisting of approximately 22 nucleotides, playing crucial roles in biological and pathological functions. Among these, miR-33a/b is particularly associated with metabolic diseases, notably obesity and atherosclerosis.

Effect of plasma free fatty acids on lung function in male COPD patients.

Inflammation and oxidative stress play a pivotal role in COPD pathogenesis. Free fatty acids (FFA) as signaling molecules through a series of G-proteins coupled receptors, play an important role in regulation of the immune system and oxidative stress. For this reason, we decided to investigate the profile of FFA in the plasma in the COPD patients.

Relationship between types and levels of free fatty acids, peripheral insulin resistance, and oxidative stress in T2DM: A case-control study.

Free Fatty Acids (FFAs) are vital for energy homeostasis and the pathogenesis of a variety of diseases, including diabetes. For the first time, we presumed and investigated the types and levels of FFAs and their links to Insulin Resistance (IR) and Oxidative Stress (OS) in T2DM. A case-control study was conducted on 60 individuals with diabetes, 60 prediabetics with IFG, and 60 control groups.

Silibinin improved the function of T cells in peripheral blood mononuclear cells (PBMCs) co-cultured with U-87 MG cell line.

Objective: Silibinin has exhibited antitumor activities. However, there are few reports about the immunomodulatory properties of silibinin on T lymphocyte function in the tumor microenvironment. Here, we determined the effects of silibinin on T cells of peripheral blood mononuclear cells (PBMCs), cultivated alone or with a human cell line of glioblastoma (U-87 MG).

Evaluation of the effect of Exercise Trainings and CGRP receptor antagonist (BIBN 4096) on mitochondrial dynamic in the hippocampus of male Wistar rats.

Background: Exercise training showed beneficial effects on brain. The purpose of the present study is to evaluate the effect of six weeks of high-intensity interval training (HIIT) and Endurance training (ET) with calcitonin gene-related peptide (CGRP) receptor antagonist on the expression of genes involved in mitochondrial dynamics and apoptosis in hippocampal tissue of male Wistar rats.

Methods: In this study, forty-two healthymale Wistar rats (8-week) were randomly divided into 6 groups (n = 7) as follow; 1) Control; 2) HIIT which performed 6 weeks of HIIT; 3) ET which performed 6 weeks of endurance training; 4) CGRPi received 10 mg/kg CGRP receptor antagonist every day at the last 2 weeks; 5) CGRPi-HIIT performed HIIT and received CGRP receptor antagonist; 6) CGRPi-ET performed ET and received CGRP receptor antagonist.

Metabolic Regulation of T cell Activity: Implications for Metabolic-Based T-cell Therapies for Cancer.

Immunometabolism is an emerging field in tumor immunotherapy. Understanding the metabolic competition for access to the limited nutrients between tumor cells and immune cells can reveal the complexity of the tumor microenvironment and help develop new therapeutic approaches for cancer. Recent studies have focused on modifying the function of immune cells by manipulating their metabolic pathways.

Psychometric properties of the physical environment problems and barriers scale in older adults' homes using an ergonomic approach.

Background: As older adults prefer to live in their homes, it is of paramount importance to examine the adaptation of the environment to the older adults' capabilities.

Objective: The aim of this study was to develop and evaluate psychometric properties of a scale to measure physical environment problems and barriers in older adults' homes using an ergonomic approach in Iran.

Methods: This mixed-method investigation was conducted in two stages in Yazd, Iran.

Quantification of the impact of factors affecting the technical performance of operating room personnel: Expert judgment approach.

Incorrect assessment of the performance shaping factors (PSFs), especially in health care systems, may lead to irreversible consequences such as death. The current study aimed to adapt PSFs taxonomy given in standardized plant analysis risk human reliability analysis (SPAR-H) technique to surgical context. PSFs taxonomy of the SPAR-H technique was revised, and more contextspecific definitions to surgical context were suggested.

Adaptation of the standardized plant analysis-risk human reliability analysis technique for the surgical setting: expert judgment approach.

Application of human reliability analysis (HRA) techniques originally developed for industrial settings to the healthcare sector may be controversial in terms of reliability and methodological level. The aim of the present study was to adapt a standardized plant analysis risk-human reliability analysis (SPAR-H) technique for application in surgical settings through suggesting more context-specific definitions for performance shaping factors (PSFs), designing precise levels and elicitation of multipliers through a domain expert judgment approach. .

Identifying barriers and problems of physical environment in older adults' homes: An ergonomic approach.

Background: The main purpose of ergonomics is environment adaptation to humans, and the root cause of the barriers and problems of the older adults is the mismatch between the home environment and their limitations.

Objective: The present study aimed to identify and explain physical environment barriers and problems among older adults' homes in Yazd, Iran.

Methods: This qualitative study was conducted as conventional content analysis.

Serum microRNA-33 levels in pre-diabetic and diabetic patients.

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia and abnormal insulin secretion. MicroRNAs are small, non-coding RNAs that are able to affect cell biological functions and act as biomarkers for some diseases such as DM. In current study, we measured serum miR-33 in three groups (n = 15) as follows; non-diabetic control, pre-diabetic, and DM patients.

Can Estradiol and Ghrelin Play a Protective Role in Epithelial Ovarian Cancer Incidence in Postmenopausal Women?

Objective: The present study aimed to investigate the association between estradiol, n-octanoylated, des-octanoylated, total ghrelin, and ghrelin/des-octanoylated ghrelin ratio levels along with pathological parameters and epithelial ovarian cancer (EOC) odds in postmenopausal women.

Materials And Methods: A case-control study was carried out on 45 patients with EOC and 33 age-matched postmenopausal women as the control group. Plasma levels of estradiol, n-octanoylated, des-octanoylated, and total ghrelin were measured by ELISA method.

Pesticide exposure and related health problems among family members of farmworkers in southeast Iran. A case-control study.

Background: Pesticides used in agriculture are some of the most common pollutants in the world. This study aimed to investigate the effects of Organophosphorus Pesticides (OPPs) and Organochlorine Pesticides (OCPs) on the families of farmworkers in the southeast of Iran.

Methods: In the present case-control study, 141 family members of farmworkers (as the case group) and 59 family members of non-farmworkers (as the controls) were recruited.

Inhibitor of Interleukin-1 Receptor-associated Kinases 1/4, Can Increase the Sensitivity of Breast Cancer Cells to Methotrexate.

Breast cancer is the most common type of cancer among women. Chemotherapy is one of the main methods of breast cancer treatment, but this method is increasingly affected due to drug resistance. One of the newly discovered factors associated with drug resistance in cancer cells is interleukin receptor-associated kinase 1 (IRAK1).

Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines.

Aging causes changes in body composition and energy balance. Estrogen plays an important role in body's metabolism. The aim of this study was to determine whether estrogen has beneficial effects on leptin responsiveness in aged mice.

Serum levels of Organochlorine Pesticides and Breast Cancer Risk in Iranian Women.

Breast cancer is a multifactorial disease and its etiology is linked to multiple risk factors. There are shreds of controversial evidence that exposure to organochlorine pesticides (OCPs) are important in the etiology of breast cancer. The present study aimed to determine the circulating levels of OCPs in patients with breast tumors in Southeastern of Iran.

Organochlorine and organophosphorus pesticides and bladder cancer: A case-control study.

Background: Exposure to pesticides is associated with an increase in the incidence of cancer. We aimed to investigate the association of serum organochlorine pesticides (OCPs) and organophosphorus pesticides (OPs) levels and GSTM1/GSTT1 gene polymorphism with bladder cancer (BC).

Methods: This study was performed on 57 patients with BC and 30 controls (C).

Organochlorine and organophosphorous pesticides may induce colorectal cancer; A case-control study.

Objectives: Among the numerous agents, genetic factors and environmental elements such as pesticides have an important role in colorectal cancer (CRC) incidence. The present study aimed to investigate the probable-role of some organochlorine pesticides (OCPs) and organophosphorous pesticides (OPPs) in patients with CRC.

Methods: In this case-control study, 42 patients with CRC and 30 healthy subjects were selected.

Epigenetic modulation of BRCA-1 and MGMT genes, and histones H4 and H3 are associated with breast tumors.

Aberrant patterns in promoter methylation of tumor-suppressor genes and posttranslational modifications of histone proteins are considered as major features of malignancy. In this study, we aimed to investigate promoter methylation of three tumor-suppressor genes (BRCA-1, MGMT, and P16) and three histone marks (H3K9ac, H3K18ac, and H4K20me3) in patients with breast tumors. This case-control study included 27 patients with malignant breast tumors (MBT) and 31 patients with benign breast tumors (BBT).